Registration Dossier

Administrative data

Description of key information

Skin: not irritating
Eye: irritating

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin:

In a study according to OECD Guideline for the Testing of Chemicals, Draft Proposal for a New Guideline, In Vitro Skin Irritation: Reconstructed Human Epidermis (RhE) Test Method (Version 7.6, 9 September 2009) under GLP, the test substance did not show any skin irritation potential and is therefore consider as not skin irritating.

Eye:

in vivo: In a GLP-study according to OECD test guideline 405, the registered substance is severly eye irritating, but all effects reverse latest after 21 days.

in vitro: In an in vitro HET-CAM study under GLP, the test substance showed potential to be severly irritating to the eye.


Effects on eye irritation: irritating

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Skin: not classified

Eye: Based on the available information, the registered substance is classified as an eye irritant (Category 2).