Registration Dossier
Registration Dossier
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EC number: 204-435-9 | CAS number: 120-92-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The study was very old and the method was not well described: no information about the test substance, the different doses and the method of calculation.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity gradient of the cycloalkanones. French language.
- Author:
- Caujolle D. and Caujolle F.
- Year:
- 1 965
- Bibliographic source:
- Journal Comptes rendus hebdomadaires des seances de l'academie des sciences, Vol. 261, p. 1781-1783
- Reference Type:
- publication
- Title:
- Toxicity of cycloalkanones for mice. French language.
- Author:
- Caujolle F., Caujolle D., Foulquier J.-L.
- Year:
- 1 962
- Bibliographic source:
- Journal Comptes rendus hebdomadaires des seances de l'academie des sciences, Vol. 254, p. 2245-2246.
Materials and methods
- Principles of method if other than guideline:
- not detailed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclopentanone
- EC Number:
- 204-435-9
- EC Name:
- Cyclopentanone
- Cas Number:
- 120-92-3
- Molecular formula:
- C5H8O
- IUPAC Name:
- cyclopentanone
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Swiss mice, weighting 20 to 22 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Details on exposure:
- Swiss mice received a single intraperitoneal injection of cyclopentanone in olive oil.
- Doses:
- not detailed
- No. of animals per sex per dose:
- No data are available.
- Control animals:
- no
- Details on study design:
- Animals were observed for 30 days after the treatment.
The paper mentioned that 982 mice were used to determine the LD50 of all the cycloalkanones tested. - Statistics:
- No data are available.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 949 mg/kg bw
Any other information on results incl. tables
The DL50 was determined at 24 hr: LD50 = 1950 mg/kg bw.
The other doses were determined within the 30 days of
observations.
Maximum no lethal dose = LD0 = 1000 mg/kg bw.
Minimum lethal dose = LD100= 2000 mg/kg bw.
The toxic effects occurred within 6 days. The mice were
restless and aggressive and then entered a stage of torpor.
Respiration was first accelerated then slower and
arrhythmic, and a drop in body temperature, lasting 5-10
hours, was also noted.
At lethal doses, prostration and coma were noted before death.
Applicant's summary and conclusion
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