Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-224-3 | CAS number: 79-77-6
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Acceptable publication which meets basic scientific principles. Due to structural similarities of the registered substance trans-ß-ionone (CAS 79-77-6) and the used test substance (mixture of α- and β-isomers, CAS 8013-90-9) the data could be taken into account for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Dermal irritating properties of essential oils and aromatic chemicals
- Author:
- Katz AE
- Year:
- 1 946
- Bibliographic source:
- cited in the RIFM/FEMA database, location 5414; The Spice Mill, 69, 46-47, 50-51
- Reference Type:
- secondary source
- Title:
- Monographs on fragrance raw materials: ionone
- Author:
- Opdyke DLJ
- Year:
- 1 975
- Bibliographic source:
- Food & Cosmetics Toxicology, 13:549, p444
- Reference Type:
- secondary source
- Title:
- Fragrance material review on ionone
- Author:
- Lalko J et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S251–S257
- Reference Type:
- secondary source
- Title:
- A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients
- Author:
- Belsito D et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S130–S167
Materials and methods
Test material
- Reference substance name:
- Ionone
- EC Number:
- 232-396-8
- EC Name:
- Ionone
- Cas Number:
- 8013-90-9
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one
- Details on test material:
- - Name of test material (as cited in study report): ionone standard
Constituent 1
Method
- Details on study design:
- - A 24 hour closed patch test was conducted on 11 male and female volunteers.
- Test material was applied undiluted to an area on the inner arm of the subjects measuring 1 cm in diameter.
- Crystalline substances were applied in the same manner except as saturated alcoholic solutions.
- Immediately following application, the area was covered with an adhesive bandage for 24 hours.
- Reactions were read daily for 5 days.
- Applications which produced visible inflammation, irritation, formation of a popular rash, or any abnormal condition of the area, were considered positive reactions.
- All positive reactions were confirmed by repetition of the test on the same subject after complete disappearance of positive systems.
- Results listed are number of positive reactions observed in the number of tests conducted
Results and discussion
- Results:
- no effects observed
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
