Registration Dossier
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EC number: 211-694-1 | CAS number: 687-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In a reverse gene mutation assay in bacteria, strains TA98, TA100, TA1535, TA1537 and TA1538 of S. typhimurium were exposed to ethyl-S-lactate at concentrations of 667, 1000, 3333, 6667 and 10000 µg/plate in the presence and absence of mammalian metabolic activation (plate co-incubation). Ethyl-S-lactate was tested up to the limit concentration of 10000 µg/plate. There was no dose-related increase in the number of revertants in any of the test strains with and without activation. The result was negative.
In a mammalian cell cytogenetics assay (chromosome aberration), primary peripheral human lymphocytes cultures were exposed to ethyl-S-lactate at concentrations of 0, 100, 333 and 1180 µg/ml with and without metabolic activation. There was no evidence of chromosome aberration induced over background. Ethyl-S-lactate is not clastogenic in human lymphocytes.
In a mammalian cell gene mutation assay (thymidine kinase (TK) locus), L5178Y mouse lymphoma cells cultured in vitro were exposed to ethyl-S-lactate, at concentrations of 0, 0.3, 1, 3, 10, 33, 100, 333 and 1180 µg/ml in the presence and absence of mammalian metabolic activation. There was no evidence of induced mutant colonies over background.
Ethyl-S-lactate was negative in all three in vitro genotoxicity tests with bacteria and mammalian cells.The substance does not have any genotoxic potential. Therefore, there is no reason to do further studies.Short description of key information:
Three in vitro genotoxicity studies (Ames test, L5178Y mouse lymphoma test, and chromosome aberration test) were performed with ethyl-S-lactate. All studies gave negative results. The substance is not genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Ethyl-S-lactate was negative in the in vitro gene mutation tests with bacteria and mammalian cells. From this it is concluded that ethyl-S-lactate is not genotoxic. No classification is required.
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