2,2,2-trifluoroethanol

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

not specified

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Remarks:

Data comes from a review, with only endpoint value (no experimental details), and therefore cannot be assigned as reliable.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

No data is available on the method applied.

Key result

Remarks on result:

other: no details on the results is available. The substance is described as miscible with water.

Conclusions:

Trifluoroethanol is described as miscible with water in this study.

Executive summary:

A US-EPA review on the toxicity of trifluoroethanol includes some physico-chemical properties; the substance is described to be miscible with water.

Reference 2

Endpoint:

water solubility

Type of information:

not specified

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Remarks:

Data comes from an online database, with only endpoint value (no experimental details), and therefore cannot be assigned as reliable.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

No data is available on the method applied.

Key result

Temp.:

20 °C

Remarks on result:

other: No details on the measured data. The substance is reported as soluble in water.

Conclusions:

Trifluoroethanol is described as soluble with water at 20°C.

Executive summary:

The german GESTIS database provides information on hazardous substances, including some physico-chemical properties; the substance is described to be soluble with water at 20°C.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Remarks:

Data comes from an online database, with only endpoint value (no experimental details), and therefore cannot be assigned as reliable.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

No data is available on the method applied.

Key result

Water solubility:

1 000 000 mg/L

Temp.:

25 °C

Remarks on result:

other: Ref.: Kirk-Othmer; (3rd ed) 10:872 (1980)

Conclusions:

The water solubility is reported to be 1000 g/L at 25°C.

Executive summary:

The SRCPhysprop database provides information on some physico-chemical properties of 25000 compounds; an experimental water solubility of 1000 g/L at 25°C is cited for the substance 2,2,2-Trifluoroethanol.

Description of key information

Trifluoroethanol is fully miscible in water. 

Key value for chemical safety assessment

Water solubility:

1 383 g/L

at the temperature of:

25 °C

Additional information

No reliable experimental data could be found, nevertheless consistent litterature data from a secondary source and two databases support the weight of evidence that TFE is fully miscible in water.

In order to fill the key value field required for CSA, the maximum significant solubility value was considered to be equal to the mean density of the substance. Indeed, the solubility of 1 kg/L cited in one database demonstrates that the substance is totally miscible in water. But the concentration of 1 kg/L is not a value of water solubility because the 1kg of substance triggers a final volume higher than 1L of water. TFE is so soluble in water that when it is added in water with increasing amount, eventually a solution of pure TFE will be obtained, which correspond to the density value.