Registration Dossier

Administrative data

First-aid measures

First aid measures
4.1. Description of first aid measures
Pay attention to self-protection.
Remove affected persons from the hazard area.
Remove contaminated or soaked clothing immediately and dispose of safely.
Always use protective equipment items (e.g. suitable respiratory equipment and suitable protective
clothing / protective gloves made of butyl rubber, fluoro rubber, chloroprene rubber, etc.).
Keep warm, position comfortably, and cover well.
Place patients who are unconscious but breathing in the stabilized lateral position.
In case of cardiac arrest, begin with cardiopulmonary reanimation (CPR) immediately.
Do not leave victims unattended.
Respiratory protection
Inhalation
Inhalation is possible if aerosols, mists, dusts, or smoke form.
No artificial respiration, mouth-to-mouth or mouth to nose. Use suitable instruments/apparatus.
Dander of poisoning!
Keep respiratory tract clear.
In case of difficulties in breathing, supply oxygen.
Call emergency doctor immediately (alarm report: cyanide / hydro-cyanic acid poisoning ).
Skin contact
No cases of cyanide intoxication have been observed to date following contact with dry sodium or
potassium cyanide on dry skin free of injuries.
Upon skin contact, wash with plenty of water and soap.
Summon an emergency physician immediately in case of intoxication symptoms (key terms: intoxication
with cyanide / prussic acid).
Eye contact
Use of special rinsing solutions with high buffer capacities (e.g. borate buffer solutions, diphoterines, etc.)
is recommended within the framework of first aid measures.
or
With eye held open, thoroughly rinse immediately with plenty of water for at least 10 minutes.
Inoculated solid matter must be reliably removed by mechanical means.
Summon an emergency physician immediately in case of intoxication symptoms (key terms: intoxication
with cyanide / prussic acid).
Ingestion
Rinse out mouth.
Immediately give large quantities of water to drink.
Do NOT induce vomiting.
Call emergency doctor immediately (alarm report: cyanide / hydro-cyanic acid poisoning ).
4.2. Most important symptoms and effects, both acute and delayed
4.3. Indication of any immediate medical attention and special treatment needed
Possible signs of poisoning:
Discrimination in 2 stages seems appropriate:
1.
Mild poisoning
2.
Severe poisoning
The following symptoms are not sufficient to ensure correct prognosis:
symptoms of the central nervous system:
Early stage
Headache, vertigo, somnolence (sleepiness), nausea.
advanced stage: seizures, coma.
Pulmonary symptoms:
Early stage: dyspnea, tachypnea.
advanced stage:
hypoventilation, Cheyne-Stokes respiration, apnea
Cardiovascular symptoms:
Early stage
hypertension, sinus arrhythmia, atrioventricular arrhythmia, bradycardia.
advanced stage:
tachycardia, complex arrhythmias, cardiac arrest.
Skin symptoms:
Early stage: rosy skin colour.
advanced stage: cyanosis.
Effect on the metabolism:
Lactate acidosis up to pH 7,1 and lactate level of 17 mmol/l are described.
Treatment:
Prevention of absorption and checking of vital functions only in the absence of risk to selfprotection !
Rapid treatment with antidotes can save lives and has priority over removal of poison !
Treatment:
Mild poisoning
Artificial respiration with 100% oxygen
Depending on the pathology and clinical findings, astrictly monitored controls of the clinical findings,
symptom-oriented treatment for pulmonary edema prophylaxis and a diagnosis (lung X-rays) are
necessary.
Antidote treatment
for example
Administration of sodium thiosulfate (12.5 g - 100-500 mg/kg weight) I.V. depending on the clinical
presentation and symptoms.
Warning! Dosage level relevant for adults weighing 70 kg.
All cyanide exposed persons should undergo continued monitoring for several hours, even if patient feels
well to ensure there are no residual or recurrent poisoning symptoms.
Treatment:
Severe poisoning
Artificial respiration with 100% oxygen
Immediate antidote administration
The medical drugs in the following list may be used in antidote treatment:
Complexing agents
1.
Administer hydroxocobalamine (Cyanokit®) 5 g i.v. (70 mg/kg b.w. in adults) by infusion over a period of
20 - 30 minutes. Administration of this dose can be repeated as required depending on the severity of
poisoning. Infusion time for repeated dose: 30 minutes to 2 hours. The only permissible route of
administration for hydroxocobalamine is i.v.!
2.
Dicobalt edetate (Kelocyanor®) 300 mg (1 ampoule) in adults, i.v. infusion time 1 - 3 minutes
Methaemoglobin-forming agent
1.
4-Dimethylaminophenol, (4-DMAP) / sodium thiosulphate: The antidote is administered in the following
order: 1.) 4-DMAP, 250 mg (3-4 mg/kg body weight) in 5 ml i.v. (1 vial) followed by 2.) Sodium
thiosulphate 12.5 g in 50 ml i.v. infusion. If the antidote has been administered and the diagnosis is not
cyanide poisoning and methaemoglobinaemia >30% is present, toluidine blue or methylene blue can be
administered to counteract the effect of the cyanide antidote. IMPORTANT: This procedure should be
carried out very cautiously and only in a clinical setting due to the possible re-release of cyanide into the
blood.
2.
Sodium nitrite (Taylor, Lilly or Pasadena Cyanide Antidote Kit) 300 - 600 mg i.v., administered over a
period of 5 to 15 minutes.

Fire-fighting measures

Firefighting measures
5.1. Extinguishing media
Suitable extinguishing media: alkali powder quenching agent
Unsuitable extinguishing media: Water
Unsuitable extinguishing media: Foam
Unsuitable extinguishing media: Carbon dioxide (CO2)
Unsuitable extinguishing media: acidic quenching agents
Unsuitable extinguishing media: acidic powder quenching agents;
5.2. Special hazards arising from the substance or mixture
May be released in case of fire:
Hydro-cyanic acid
5.3. Advice for firefighters
Contaminated extinguishing water must be treated at a suitable disposal plant in accordance with waste
management laws.
Water used to extinguish fire should not enter drainage systems, soil or stretches of water.
Ensure there are sufficient retaining facilities for water used to extinguish fire.
In case of fire, remove the endangered containers and bring to a safe place, if this can be done safely.
Contaminated fire-extinguishing water must be disposed of in accordance with the regulations issued by
the appropriate local authorities.
Fire residues should be disposed of in accordance with the regulations.
Keep out unprotected persons.
In the event of fire, wear self-contained breathing apparatus.
full protective suit

Accidental release measures

Accidental release measures
6.1. Personal precautions, protective equipment and emergency procedures
Wear personal protective equipment; see section 8.
Keep out unprotected persons.
Keep unauthorized persons away.Avoid dust formation.
Ensure sufficient ventilation. Avoid skin contact because of the danger of skin absorption.
6.2. Environmental precautions
Do not allow the product into the following compartments:
soil
stretches of water
drainage systems
Cyanide-containing sewage water and solutions must be decontaminated before entering a public canal
network or stretch of water.
If the product contaminates rivers and lakes or drains inform respective authorities.
6.3. Methods and material for containment and cleaning up
1. solid:
Pick up mechanically. Collect in suitable containers.
Reuse or eliminate absorbed material according to the regulations in force.
To absorb spilled substance an approved industrial vacuum cleaner is recommended. If necessary, the
spilled substance should be moistened.
2. solution:
Absorb with liquid-binding material, e. g.: inert absorbent, diatomaceous earth or acid neutralizer
Pick up mechanically. Collect in suitable containers.
Reuse or eliminate absorbed material according to the regulations in force.
1 and 2:
Pack and label wastes like the pure substance. Do not detach label from the delivery containers prior to
disposal.
6.4. Reference to other sections
Wear personal protective equipment; see section 8.

Handling and storage

Handling and storage
7.1. Precautions for safe handling
Wear personal protective equipment.
Store under lock and key or in a way that only skilled persons have access to it.
Ensure ventilation when opening container. Traces of HCN may adhere to product.
Seal container hermetically immediately after use.
Avoid residues of the product on the containers.Be careful when opening the package, since toxic and
caustic gases and vapours may escape.
7.2. Conditions for safe storage, including any incompatibilities
Advice on protection against fire and explosion
The product itself does not burn.
Ensure there are sufficient retaining facilities for water used to extinguish fire.
see section 5.
In case of release hydrocyanic acid:
Formation of flammable or explosive dust/air mixtures possible.
Storage
Store in original container.
Keep container tightly sealed and store in a dry, well-ventilated place.
clean, dry, lockable.
Keep locked up or in an area accessible only to qualified or authorised persons.
Inadequate materials are:
Aluminium
Do not store together with: acid and acidic salts.
Keep away from food, drink and animal feedingstuffs.
Further information
Protect from sunlight, warmth and heat.
In order to ensure due transportation, make certain that stacks are of the correct height, containers are
securely fastened so as not to fall off, and labelled according to the regulations.
Dust explosion class
not applicable
7.3. Specific end use(s)
For more details see annexes Exposure scenario.

Transport information

Land transport (ADR/RID)

UN number:
UN 1680
Proper shipping name and description:
POTASSIUM CYANIDE, SOLID
Chemical name:
Potassium cyanide
Language:
English
Class:
6.1
Packaging group:
I
Special Provisions:
ADR: Tunnel Restriction Code: (C/E)
Do not store together with acids (danger of toxic gases) or with foodstuffs, consumables and feedstuffs.

Inland waterway transport (ADN(R))

UN number:
UN1680
Proper shipping name and description:
POTASSIUM CYANIDE, SOLID
Chemical name:
Potassium cyanide
Language:
English
Class:
6.1
Packaging group:
I
Remarks
Do not store together with acids (danger of toxic gases) or with foodstuffs, consumables and feedstuffs.

Marine transport (IMDG)

UN number:
UN 1680
Proper shipping name and description:
POTASSIUM CYANIDE, SOLID
Chemical name:
Potassium cyanide
Class:
6.1
Packaging group:
I
EmS code:
F-A, S-A
Marine pollutant
Remarks
Do not stow in external container rows
FOR USA ONLY: When shipping in, by or via USA note of the Reportable Quantity-Regulation!
Do not store together with acids (danger of toxic gases) or with foodstuffs, consumables and feedstuffs.

Air transport ICAO/IATA

UN number:
UN 1680
Proper shipping name and description:
Potassium cyanide, solid
Chemical name:
Potassium cyanide
Class:
6.1
Packaging group:
I
Remarks
IATA-C: FOR USA ONLY: When shipping in, by or via USA note of the Reportable Quantity-
Regulation!
IATA-P: FOR USA ONLY: When shipping in, by or via USA note of the Reportable Quantity-
Regulation!
Do not store together with acids (danger of toxic gases) or with foodstuffs, consumables and feedstuffs.

Additional transport information

Additional transport information
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code:
for transportapproval see regulatory information

Exposure controls / personal protection

Control parameters
 Potassium cyanide
CAS-No. 151-50-8 EC-No. 205-792-3
Control parameters 5 mg/m3 Short Term Exposure Limit (STEL):(EU ELV)
Indicative
Control parameters Skin designation:(EU ELV)
Can be absorbed through the skin.
Control parameters 1 mg/m3 Time Weighted Average (TWA):(EU ELV)
Indicative
 Hydrogen cyanid
CAS-No. 74-90-8 EC-No. 200-821-6
Control parameters 0,9 ppm Time Weighted Average (TWA):(EU ELV)
1 mg/m3
Indicative
Control parameters 4,5 ppm Short Term Exposure Limit (STEL):(EU ELV)
5 mg/m3
Indicative
Control parameters Skin designation:(EU ELV)
Can be absorbed through the skin.

DNEL/DMEL values
End Use general populace
Remarks not applicable
Product not intended for consumers
End Use Worker
Routes of exposure dermal
Possible health damage Acute - systemic effects
Value 4,03 mg/kg bodyweight/day
Remarks Acute toxicity
End Use Worker
Routes of exposure Inhalation
Possible health damage Acute - systemic effects
Value 12,5 mg/m3
Remarks Acute toxicity
End Use Worker
Routes of exposure dermal
Possible health damage Long-term - systemic effects
Value 0,14 mg/kg bodyweight/day
Remarks Repeated dose toxicity
End Use Worker
Routes of exposure Inhalation
Possible health damage Long-term - systemic effects
Value 0,94 mg/m3
Remarks Repeated dose toxicity

PNEC values
Freshwater
Value 0,001 mg/l
Remarks Test substance
C N -

marine water
Value 0,001 mg/l
Remarks Test substance
C N -

water - intermittent releases
Value 0,005 mg/l
Remarks Test substance
C N -

Microorganisms
Value 0,05 mg/l
Remarks Test substance
C N -

Fresh water sediment
Value 0,004 mg/kg (dry weight)
Remarks Test substance
C N -

marine water sediment
Value 0,004 mg/kg (dry weight)
Remarks T est substance
C N -

soil
Value 0,007 mg/kg (dry weight)
Remarks Test substance
C N -

8.2. Exposure controls
Engineering measures
Ensure suitable suction/aeration at the work place and with operational machinery.
Provide for installation of emergency shower and eye bath.
Exposure controls
Suitable measuring processes are:
Potassium cyanide
OSHA method ID 120
NIOSH method 7904
Hydro-cyanic acid
OSHA method ID 120
Personal protective equipment
Respiratory protection
If Hydrogen cyanide occurs:
wear a self contained respiratory apparatus
Note time limit for wearing respiratory protective equipment.
If dust / aerosols occurs:
Respirator with B-P3 combination filter
Respirator with ABEK-P3 combination filter
(Germany)
Hand protection
Glove material Natural rubber (NR), for example, Cama Clean 708, Kächele-Cama Latex GmbH (KCL), Germany
Material thickness 0,5 mm
Break through time >= 480 min
Method DIN EN 374
Glove material Nitrile, for example, Dermatril 740, Kächele-Cama Latex GmbH (KCL), Germany
Material thickness 0,11 mm
Break through time >= 480 min
Method DIN EN 374
Glove material Nitrile, for example, Camatril (731), Kächele-Cama Latex GmbH (KCL), Germany
Material thickness 0,33 mm
Break through time >= 480 min
Method DIN EN 374
Glove material Polychloroprene with natural-latex liner., for example, Camapren 722, Kächele-Cama Latex GmbH (KCL), Germany
Material thickness 0,6 mm
Break through time >= 480 min
Method DIN EN 374
Eye protection
wear basket-shaped glasses
Skin and body protection
Wear chemical protective suit.
During cleaning work: rubber or plastic boots.
Hygiene measures
Avoid contact with skin.
After contact with skin, wash immediately with plenty of water.
Do not eat, drink, smoke, or sniff while at work. Wash your hands and/or face before breaks and before
termination of work.
Preventive skin protection
Keep working clothes separately.
Avoid contaminating clothes with product.
Immediately change moistened and saturated work clothes.
Immediately rinse contaminated or saturated clothing with water.
Protective measures
Wear suitable protective clothing, gloves and eye/face protection.
The personal protective equipment used must meet the requirements of Regulation (EU) 2016/425 and
amendments (CE certification).
It should be defined in the work place in the form of a risk analysis according to Regulation (EU) 2016/425
and amendments.
The work-place related airborne concentrations have to be kept below of the indicated exposure limits.
If workplace exposure limits are exceeded and/or larger amounts are released (leakage, spilling, dust) the
indicated respiratory protection should be used.
All precautionary measures indicated have to be observed.

Stability and reactivity

Stability and reactivity
10.1. Reactivity
No further information available
10.2. Chemical stability
No further information available
10.3. Possibility of hazardous reactions
Possibility of hazardous reactions No further information available
10.4. Conditions to avoid
Hydrogen cyanide forms if heated above 300 °C.
10.5. Incompatible materials
Under the action of acids (as well as carbon dioxide !) hydrocyanic acid is released which is combustible
and may react with air to explosive gas mixtures.Keep away from acidic salts.
10.6. Hazardous decomposition products
HCN: Hydrogen cyanide (hydrocyanic acid)

Disposal considerations

Disposal considerations
13.1. Waste treatment methods
Product
Disposal according to local authority regulations.
Recommendation:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Pack and label wastes like the pure substance. Do not detach label from the delivery containers prior to
disposal.
Refer to manufacturer/supplier for information on recovery/recycling.
Cyanide-containing sewage water and solutions must be decontaminated before entering a public canal
network or stretch of water. Observe national regulations.
Uncleaned packaging
Rinse empty containers with water three times, test the last rinsing water for content of cyanide residues.
Treat and detoxify with: Hydrogen peroxide.
pH Value = 11
Recommended cleaning agent: Water
Do not reuse empty containers and dispose of in accordance with the regulations issued by the
appropriate local authorities.
Waste Key Number
duty of proof: yes;
The waste key number must be determined as per the European Waste Types List (decision on EU Waste
Types List 2000/532/EC) in cooperation with the disposal firm / producing firm / official authority