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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
other: review article
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review article providing general information on cyanide toxicity

Data source

Reference
Reference Type:
secondary source
Title:
Noxious Gases and Vapours I: Carbon Monoxide, Cyanides, Methemoglobin and Sulfhemoglobin
Author:
Reiders, F
Year:
1971
Bibliographic source:
Drill's Pharmacology in Medicine, 4th ed, DePalma, J.R. (ed). New York, NY, McGraw-Hill Book Co., P 1180-1205.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Review of information concerning human exposure and poisoning.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
no

Results and discussion

Signs and symptoms of toxicity:
yes
Remarks:
death
Dermal irritation:
not specified
Absorption in different matrices:
Dermal absorption of 100 mg/kg on human skin is associated with death. Fatalities have occurred at skin absorption of 5% cyanide solutions.

Applicant's summary and conclusion

Conclusions:
Human fatalities have been associated with solutions of cyanide salts at 5%. The dermal threshold is 100 mg/kg bw.