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Administrative data

Key value for chemical safety assessment

Genetic toxicity in vivo

Link to relevant study records
Reference
Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
GLP compliance:
not specified
Type of assay:
micronucleus assay
Species:
mouse
Strain:
other: undefined
Sex:
not specified
Duration of treatment / exposure:
undefined
Sex:
not specified
Genotoxicity:
negative
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified
Conclusions:
Interpretation of results (migrated information): negative
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Additional information from genetic toxicity in vivo:

The substance did not show genotoxic effects in an Ames tests with Salmonella typhimurium TA 98, TA 100, TA 1535 and TA 1537 (50 -5000 microgram/plate), nor in the V79 Chinese hamster lung cell test (0 -5000 mg/l), all with and without metabolic activation.

The substance showed no genotoxic effects in an in vivo micronucleus assay.

Justification for classification or non-classification

The substance did not show any genotoxic effect in vitro nor in vivo and thus there is no requirement for classification