Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- Not reported
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: There were not enough available information to adequately rate the quality of this study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of acute toxicity of phenylglycidyl ether with special regard to percutaneous absorption
- Author:
- Czajkowska, T.
- Year:
- 1 972
- Bibliographic source:
- Czajkowska, T. and Stetkiewicz, J. (1972) Evaluation of acute toxicity of phenylglycidyl ether with special regard to percutaneous absorption. Med. Pr., 23; 363-371.
Materials and methods
- Principles of method if other than guideline:
- A single application of PGE was made to the skin of white Wistar Rats, the observation period was 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-epoxypropyl phenyl ether
- EC Number:
- 204-557-2
- EC Name:
- 2,3-epoxypropyl phenyl ether
- Cas Number:
- 122-60-1
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 2-(phenoxymethyl)oxirane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 2 160 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: Histopathological examination of the skin 18 hours after treatment revealed necrosis, epithelial exfoliation and oedema. After 14 days, scar formation, acanthosis and swelling of the dermis were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results of this study estimate the dermal LD50 of phenylglycidyl ether to be 2160 mg/kg bw.
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