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Endpoint specific guidance (ECHA, 2012) indicates that absorption of substances following exposure by inhalation, skin contact or ingestion may be predicted based on log Pow and water solubility. Experimentally determined results for Fatty acids, tall oil, oligomeric reaction products with maleic anhydride and rosin, calcium magnesium zinc salts and the analogue read-across substances Rosin, maleated, Rosin, fumarated and Rosin are as follows:

Substance

Log Pow

Solubility (mg/l)

Fatty acids, tall oil, oligomeric reaction products with maleic anhydride and rosin, calcium magnesium zinc salts

0.4 (pH 5.43)

<10

Rosin, maleated

2.2 – 5.89 (unbuffered)

1.38

Rosin, fumarated

2.8 (pH 3.93 – 4.47)

c.9.0

Rosin

1.9->6.0 (pH 2)

30>6 (pH7)

0.9

ECHA (2012) indicates that uptake of substances by the lung and by the gastrointestinal tract is favoured by moderate log P values (between -1 and 4) with micellular solubilisation favoured where log P is >4 and water solubility is low (< 1 mg/l). Data summarised above indicate that the log Pow for Fatty acids, tall oil, oligomeric reactions products with maleic anhydride and rosin, calcium magnesium zinc salts, Rosin, maleated and Rosin, fumarated is less than 4 suggesting that some uptake after exposure via these routes may be possible although the extent is unclear. No clear conclusion can be reached for Rosin.

Dermal absorption of highly water soluble substance may occur where the log Pow is between 1-4 with log Pow values between 2 and 3 favouring uptake. When log Pow exceeds 4, penetration may be limited by the rate of transfer between the stratum corneum and epidermis although uptake of a substance by the stratum corneum will be high. Uptake of substances where log Pow exceeds 6 will be low (ECHA, 2012). Data summarised above suggest a similar situation for dermal uptake as with uptake from lung and gastrointestinal tract i.e. the log Pow for Fatty acids, tall oil, oligomeric reactions products with maleic anhydride and rosin, calcium magnesium zinc salts, Rosin, maleated and Rosin, fumarated suggests that some uptake by skin may be possible although the extent is unclear, while no clear conclusion can be reached for Rosin.

Although no experimental toxicokinetic data are currently available for the source or target substances, work is underway to assess the intestinal bioavailability of Fatty acids, tall oil, oligomeric reactions products with maleic anhydride and rosin, calcium magnesium zinc salts using an ex vivo gut sac model.