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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: study data do not give sufficient experimental details

Data source

Reference
Reference Type:
publication
Title:
Alergens in rubber products
Author:
Kanto, H.; et al.
Year:
1999
Bibliographic source:
Toho Igakkai Zasshi, 46(3), 240-250

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: patch-test with dermatitis cases
Principles of method if other than guideline:
other: patch-test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
EC Number:
204-327-1
EC Name:
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
Cas Number:
119-47-1
Molecular formula:
C23H32O2
IUPAC Name:
2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
Details on test material:
no data

Method

Type of population:
not specified
Controls:
no data
Route of administration:
dermal

Results and discussion

Results of examinations:
0/16 and 0/91 positive skin reactions in contact dermatitis patients

Any other information on results incl. tables

Patch-test Reading:

negative

0/16

0/91

Applicant's summary and conclusion

Executive summary:

The test substance 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol was negative in the patch-test (Kanto 1999).