Registration Dossier
Registration Dossier
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EC number: 203-765-0 | CAS number: 110-41-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The test substance was assessed for toxicity to aquatic algae according to OECD guideline 201. The 72 hour EC50 was 0.18 mg/L and the NOEC was 0.089 mg/L, based on growth rate.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.18 mg/L
- EC10 or NOEC for freshwater algae:
- 0.089 mg/L
Additional information
The effects of the test substance on the growth of the unicellular green alga, Pseudokirchneriella subcapitata, were determined during a 72-hour growth inhibition toxicity test conducted in accordance with OECD Guideline 201. Due to the volatile nature of the test substance, the test was conducted in filled and sealed vessels.
Based on initial 0-hour measured concentrations, the 72-hour EyC50 and the 0-72 hour EbC50 and ErC50 values were calculated to be 0.11, 0.11 and 0.18 mg/L, respectively. The corresponding NOEC values for yield, biomass and specific growth rate after 72 hours were 0.057, 0.057 and 0.089 mg/L, respectively.
The preferred observational endpoint in this study is algal growth rate inhibition because it is not dependent on the test design (see Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance v1.1). Thus the 72 hr ErC₅₀ of 0.18mg/L and NOEC of 0.089mg/L based on growth rate are used for classification purposes.
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