Registration Dossier
Registration Dossier
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EC number: 203-765-0 | CAS number: 110-41-8
Vapour pressure
Administrative data
Link to relevant study record(s)
Description of key information
Vapour pressure: 2.4 Pa at 20°C (isothermal effusion method, OECD 104)
Key value for chemical safety assessment
- Vapour pressure:
- 2.4 Pa
- at the temperature of:
- 20 °C
Additional information
The vapour pressure of 2-methylundecanal has been determined in two independent studies. The first, according to the gas saturation method of OECD TG104, gave a value of 0.85 Pa at 20°C (Givaudan 2012). Since the validity of this study was challenged by ECHA, a second study has been performed. The method chosen was the isothermal effusion method of OECD TG104 (Givaudan 2017). The weight loss of the test item was measured continuously as a function of time at defined isothermal temperatures; 35, 40, 45 and 50°C. The evaporation rate of the test item was calculated from the weight loss of the compound. From the resulting vapour pressure regression curve, the vapour pressure of the test item at 20°C was estimated to be 2.4 Pa.
Taking into account that the vapour pressure is a physico-chemical property that spans over 15 orders of magnitude (10-10Pa to 105Pa), the different approaches of the methods (vapour pressure of the target molecule in the case of the gas saturation method) and total vapour pressure of the sample tested (target molecule + impurities) in the case of the isothermal effusion method, and the experimental error of both methods used (estimated reproducibility is reported to be up to 50 % in the OECD 104 Guideline for either of the two methods), the measured vapour pressure values are considered to be in agreement, confirming the validity of the 2012 study.
In response to the ECHA decision requesting a new study to be performed, the value of the 2017 study was adapted as key study, vapour pressure of 2.4 Pa (20°C) was been chosen as the key value for chemical safety assessment.
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