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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data originate from collection of data by the American Conference of Governmental Industrial Hygienists.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Documentation of the Threshold Limit Values and Biological Exposure Indices
Author:
Not specified
Year:
1991
Bibliographic source:
American Conference of Governmental Industrial Hygienists, 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, p. 943

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The application of the substance on the intact skin of a rabbit for at least 1 hour.
GLP compliance:
not specified
Test type:
other: Exposure for 1 hour

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
At least 1 hour.
Doses:
Reported: at least 3 grams per kg bw.
No. of animals per sex per dose:
Not specified.
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD100
Effect level:
3 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Application of 3 grams or more per kg of body weight upon the intact skin of a rabbit for 1 hour or more always produced death.

Applicant's summary and conclusion

Interpretation of results:
other: Based on these data it is not possible to give a reliable interpretation of the dermal toxicity of N-methylaniline. According to the CLP-regulation the highest value for classification is a LD50 of 2000 mg/kg bw.
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
N-Methylaniline caused acute lethal poisoning by percutaneous absorption at applications of 3000 mg/kg body weight and higher.