Registration Dossier

Administrative data

Description of key information

The key value for acute oral exposure is derived from a reliable study (Klimisch code 1). The value for inhalation  is based on a study with aniline and concerns a LOAEC based on induction of 5% MetHb in dogs. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
discriminating dose
512 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
discriminating conc.
165 mg/m³

Additional information

N-Methylaniline -like aniline- is readily absorbed irrespective the route of administration. Further, the symptoms and effects observed are similar for all routes of administration and identical to those observed after acute exposure to aniline.

Justification for classification or non-classification

Based on the fact that N-methylaniline is toxic irrespective the route of administration it is justified that the current classification includes "acute toxic" for all three routes.