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The 48h-LC50 for N-methylaniline in fish ranges from 38 to 91 mg/L. Early life stages were three orders of magnitude more sensitive with an 96h-LC50 of 76 ug/L and a NOEC of 21 ug/L.

Two studies testing N-methylaniline in D. magna gave different results for the 48h-EC50, 0.174 mg/L (von der Ohe et al., 2005) and 5.6 mg/L (Min. of the Environ. Japan, 2010). The 48h-EC50 for invertebrates exposed to aniline and other methylanilines ranged from 0.08 to 0.52 mg/L. Hence the 48h-EC50 value of 0.174 mg/L appears to be the most reliable for N-methylaniline. For prolonged exposure an EC50 value of 0.59 mg/L and a NOEC of 0.29 mg/L were found (Min. of the Environ. Japan, 2010). Comparing these results with the acute EC50 of 0.174 mg/L and the 21-d EC50 of 0.021 mg/L for aniline, the actual value of the 21d-EC50 for N-methylaniline is 0.09 mg/L and the NOEC in the range of 0.02 mg/L.  

The 72h-EC50 value for algae ranged from 3.8 mg/L. The ultimate NOEC corresponds with 0.14 mg/L.

Comparing the three trophic levels, the early life stages of zebra-fish and the daphnids appear to be the most sensitive. The most reliable is the NOEC for the early life stages of fish and this is used for further risk assessment.