Registration Dossier

Administrative data

Description of key information

Orientating Oral (Rat, comparable to OECD TG 401): LD50 > 5 g/kg
[Schering AG, Report No. 4954, 1984-01-24]

Key value for chemical safety assessment

Additional information

In an orientating toxicity study the single oral administration of the test substance (ZK 74.804) to male rats at doses of 0.25, 0.5, 1.0, 2.0, 3.5 and 5 g/kg was tolerated without any mortality or compound-related macroscopic pathological signs. Main clinical findings were spastic gait and ruffled fur which were observed on the first day after application in all dose groups. From day 2 onwards all animals were without findings.

The acute oral toxicity of AD-Cyanhydrin in rats is therefore above 5 g/kg body weight.

Justification for classification or non-classification

Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.