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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute toxicity of N-Phenyl-N-[(trichloromethyl)thio]benzenesulphonamide was investigated in different studies. After oral dosing in rat the LD0 was >= 2500 mg/kg and in rabbits the LD0 was >= 1000 mg/kg; in both cases the highest doses tested. After dermal application of 500 mg/kg to 5 rats, no animals showed any intoxication, and consequently the dermal discriminating dose was 500 mg/kg.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study conducted according to accepted scientific criteria
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
15 male rats per dose were dosed by gavage. Symptoms and deaths were recorded.
GLP compliance:
no
Test type:
standard acute method
Species:
rat
Strain:
Wistar
Sex:
male
Route of administration:
oral: gavage
Vehicle:
other: aceton:oil 1:10
Doses:
100, 250, 500, 1000, 2500 g/kg bw
No. of animals per sex per dose:
15 males per group
Control animals:
no
Sex:
male
Dose descriptor:
LD0
Effect level:
> 2 500 mg/kg bw
Based on:
test mat.

Dose level; No of deaths/ no of animals with symptoms/no of deaths.

100; 0/0/15

250; 0/15/15; Animals were free of symptoms on day 2

500;0/15/15; Animals were free of symptoms on day 2

1000; 0/15/15; Animals were free of symptoms on day 4

2500; 0/15/15; Animals were free of symptoms on day 4

Interpretation of results:
GHS criteria not met
Executive summary:

No animal died even at the highest dose 2500 mg/kg.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 500 mg/kg bw
Quality of whole database:
reliable study in rats

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: highest dose tested: 500 mg/kg
Qualifier:
no guideline followed
Principles of method if other than guideline:
5 male rats were dosed with a single dose of 500 mg/kg (25% solution; vehicle oil/acetone 10/1) for 7 days
GLP compliance:
no
Test type:
other: single dose experiment
Species:
rat
Strain:
Wistar
Sex:
male
Type of coverage:
other: open; rats weared a dog-collar
Vehicle:
other: oil acetone 10:1
Duration of exposure:
7 days
Doses:
500 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Sex:
male
Dose descriptor:
discriminating dose
Effect level:
>= 500 mg/kg bw

No symptoms were observed; discriminating does 500 mg/kg

Interpretation of results:
study cannot be used for classification
Executive summary:

No symptoms were observed in 5 rabbits at 500 mg/kg, the only dose investigated.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
500 mg/kg bw
Quality of whole database:
reliable study in rats

Additional information

Acute toxicity of N-Phenyl-N-[(trichloromethyl)thio]benzenesulphonamide was investigated in different studies. After oral dosing in rat the LD0 was >= 2500 mg/kg and in rabbits the LD0 was >= 1000 mg/kg; in both cases the highest doses tested. After dermal application of 500 mg/kg to 5 rats, no animals showed any intoxication, and consequently the dermal discriminating dose was 500 mg/kg.

Justification for classification or non-classification

Based on the oral LD0>=2500 mg/kg and the dermal discriminating dose of >= 500 mg/kg no classification is proposed.