Registration Dossier
Registration Dossier
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EC number: 202-888-7 | CAS number: 100-79-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Literature data with limited details
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Ref. substance: 5233 Isopropylidene Glycerol
- Author:
- O’Neil M.J. Smith A. Heckelman P.E. Obenchain J.R.Jr. Gallipeau J.A.R. D’Arecca M.A. Budavari S.
- Year:
- 2 001
- Bibliographic source:
- The Merck Index : an encyclopedia of chemicals, drugs, and biological, Thirteenth edition
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Test type:
- other: No data
Test material
- Reference substance name:
- 2,2-dimethyl-1,3-dioxolan-4-ylmethanol
- EC Number:
- 202-888-7
- EC Name:
- 2,2-dimethyl-1,3-dioxolan-4-ylmethanol
- Cas Number:
- 100-79-8
- Molecular formula:
- C6H12O3
- IUPAC Name:
- (2,2-dimethyl-1,3-dioxolan-4-yl)methanol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 7 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- No data
- Clinical signs:
- other: other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
No data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 of the submitted substance, 2,2-Dimethyl-1,3-dioxolane-4-methanol, has been reported to be 7000 mg/kg in rats in literature data.
- Executive summary:
The only data available for acute oral toxicity of the submitted substance 2,2-Dimethyl-1,3-dioxolane-4-methanol was a literature data with no details on test method and results. The oral LD50 of the submitted substance has been reported to be 7000 mg/kg in rats. Therefore the substance cannot be classified for acute oral toxicity according to the Regulation (EC) N° 1272-2008 (CLP) and to the GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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