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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is rated a "2" because appropriate testing methods were used; however, the study predates GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
1,2-Benzenedicarboxylic acid, di-C9-11-branched alkyl esters, C10-rich
EC Number:
271-091-4
EC Name:
1,2-Benzenedicarboxylic acid, di-C9-11-branched alkyl esters, C10-rich
Cas Number:
68515-49-1
IUPAC Name:
bis(8-methylnonyl) phthalate
Constituent 2
Reference substance name:
1,2-benzenedicarboxylic acid, di-C9,C10 and C11 branched alkyl ester, C10 Rich
IUPAC Name:
1,2-benzenedicarboxylic acid, di-C9,C10 and C11 branched alkyl ester, C10 Rich

Test animals / tissue source

Species:
rabbit
Strain:
other: Albino

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
Concentration: 0.1 undiluted
Amount applied: 0.1 ml
Duration of treatment / exposure:
single exposure
Observation period (in vivo):
4 days
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24-48 hours
Score:
0
Reversibility:
fully reversible
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24-48 h
Score:
0
Reversibility:
fully reversible

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Conclusions:
Under the conditions of this study, the test substance was considered minimally irritating.
Executive summary:

In a study conducted in 6 rabbits, undiluted DIDP produced only slight signs of irritation in the conjunctiva at 1, 4 and 24-hour observation time (redness score 1 or 2 and discharge at 1 hour, redness score 1 at 4 hours and redness score 1 in 1 animal at 24 hours). All the eyes were normal at 48, 72 and 96 hours.