Registration Dossier
Registration Dossier
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EC number: 214-275-1 | CAS number: 1119-34-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The short-term toxicity of L-arginine-HCl to aquatic invertebrates (daphnia) is estimated by read-across from L-arginine.
The test results for acute toxicity of L-arginine to daphnia magna were:
EC50 = 1.8 g/l; EC100 = 5.6 g/l; NOEC (mobility) was estimated to be 1.0 g/l and NOEC (condition) was estimated to be < 1.0 g/l.
These results are converted based upon the retion of the molecular weight.
The results applying for Arg-HCl are: EC50 = 2.2 g/l; EC100 = 6.8 g/l; NOEC (mobility) was estimated to be 1.2 g/l and NOEC (condition) was estimated to be < 1.2 g/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.2 g/L
Additional information
A limit test according to OECD 202 did not show any adverse effects to Daphnia magna at a test concentration of 1 g/l. A subsequent test according to OECD 202 with higher test concentrations showed the following results:
EC50 = 1.8 g/l; EC100 = 5.6 g/l; NOEC (mobility) was estimated to be 1.0 g/l and NOEC (condition) was estimated to be < 1.0 g/l.
There is weight of evidence from the behaviour of L-arginine-HCl in aqueous solution that read-across from L-arginine to L-arginine-HCl is justified for the endpoint short-term toxicity to aquatic invertebrates.
These results from Arg are converted to Arg-HCL based upon the retion of the molecular weight.
The results applying for Arg-HCl are: EC50 = 2.2 g/l; EC100 = 6.8 g/l; NOEC (mobility) was estimated to be 1.2 g/l and NOEC (condition) was estimated to be < 1.2 g/l.
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