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EC number: 306-232-1
CAS number: 96690-38-9
NOEC (14 d): ≥ 14.2 mg/L for activated sludge microorganisms (OECD 301B)
Since no studies investigating the toxicity to microorganisms of
Fatty acids, C16-18, 2-octyldodecyl esters (CAS 96690-38-9) are
available for this endpoint, in accordance to Regulation (EC) No.
1907/2006 Annex XI, 1.5 a read across to the structurally related
category member 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) was
conducted. The read-across substance is characterized by the same
alcohol component (2-octyldodecan-1-ol) and a very similar fatty acid
(C16-18 compared to C18iso (target)). This read-across is justified in
detail in the overall summary (IUCLID Section 6.1) and within the
category justification in IUCLID Section 13. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substances were used
for the assessment. Nevertheless, as it can be seen in the data matrix
of the category justification in section 13 and the overall summary, all
reliable data in the category support the hazard assessment of each
category member by showing a consistent pattern of results.
Since no studies on the toxicity to aquatic microorganisms are
available for the read-across substance 2-octyldodecyl isooctadecanoate
a ready biodegradability study is used to derive a NOEC for the toxicity
to aquatic microorganisms. If a compound degrades well in a ready
biodegradability test, or does not inhibit the degradation of a positive
control at a certain concentration, this concentration can be used as a
NOEC value. This approach is in accordance with the Guidance on
information requirements and chemical safety assessment (Chapter R.7b:
Endpoint specific guidance, ECHA 2008). A substance can be assumed to be
not inhibitory to aquatic microorganisms, if in the toxicity control of
a ready biodegradation test, more than 25% degradation based on CO2
evolution occurred within 14 days (OECD guideline 301). For
2-octyldodecyl isooctadecanoate (CAS 93803-87-3) a biodegradation test
conducted according to OECD guideline 301B is available
(Desmares-Koopmans, 1998). The test includes a toxicity control, which
contains 14.2 mg/L of the test substance and 39.85 mg/L of the reference
material. The toxicity control attained 78.1% degradation after 14 days
of incubation. Hence, the substance is not toxic to aquatic
microorganisms and a NOEC of ≥ 14.2 mg/L was derived.Based on the
available result from one structurally related read-across substance (in
accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is
characterized by a similar ecotoxicological profile and comparable
structure, it can be concluded that Fatty acids, C16-18, 2-octyldodecyl
esters will not exhibit effects to activated sludge microorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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