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EC number: 306-232-1
CAS number: 96690-38-9
No effects up to the limit of water solubility (OECD 201).
Since no studies investigating the toxicity to aquatic algae of
Fatty acids, C16-18, 2-octyldodecyl esters (CAS 96690-38-9) are
available for this endpoint, in accordance to Regulation (EC) No.
1907/2006 Annex XI, 1.5 a read across to the structurally related
category member 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) was
conducted. The read-across substance is characterized by the same
alcohol component (2-octyldodecan-1-ol) and a very similar fatty acid
(C16-18 compared to C18iso (target)). This read-across is justified in
detail in the overall summary (IUCLID Section 6.1) and within the
category justification in IUCLID Section 13. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substances were used
for the assessment. Nevertheless, as it can be seen in the data matrix
of the category justification in section 13 and the overall summary, all
reliable data in the category support the hazard assessment of each
category member by showing a consistent pattern of results.
The study with the read-across substance 2-octyldodecyl
isooctadecanoate was conducted according to OECD 201 (GLP) with the
freshwater algae Selenastrum capricornutum (Bogers, 1998). Water
Accommodated Fractions (WAF) of nominal 10 and 100 mg/L were prepared
and tested under static conditions.A chemical analysis of the test
substance concentrations in the test vessels was not possible since no
applicable method could be established due to the very low water
solubility to detect test concentrations. An inhibition of growth
(31.2%) was observed after 72 h in the WAF test solution of 100 mg/L,
whereas no inhibition was observed in the WAF test solution of 10 mg/L.
It was reported that this effect is probably related to insoluble
particles which might have adsorbed fractions of light needed for algal
cell growth. Since both test substance concentrations are above water
solubility it can be concluded that the EC50 and the NOEC exceed the
maximum water solubility of the test substance. An EL50 of > 100 mg/L
and a NOELR of ≥ 100 mg/L were derived.Based on the available result
from one structurally related read-across substance (in accordance to
Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a
similar ecotoxicological profile and comparable structure, it can be
concluded that Fatty acids, C16-18, 2-octyldodecyl esters will not
exhibit effects to aquatic algae up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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