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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

No effects up to the limit of water solubility (OECD 203).

Key value for chemical safety assessment

Additional information

Since no studies investigating the short-term toxicity to fish of Fatty acids, C16-18, 2-octyldodecyl esters (CAS 96690-38-9) are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to the structurally related category member 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) was conducted. The read-across substance is characterized by the same alcohol component (2-octyldodecan-1-ol) and a very similar fatty acid (C16-18 compared to C18iso (target)). This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substances were used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results. The study with the read-across substance 2-octyldodecyl isooctadecanoate was conducted according to OECD 203 (GLP) investigating the short-term toxicity to fish (Cyprinus carpio) (Bogers, 1998).Water Accommodated Fractions (WAF) of nominal 10 and 100 mg/L were prepared and tested under static conditions. A chemical analysis of the test substance concentrations in the test vessels was not possible since no applicable method could be established due to the very low water solubility to detect test concentrations. No mortality was observed after 96 h and therefore a LL50 of > 100 mg/L was derived.

Based on the available result from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Fatty acids, C16-18, 2-octyldodecyl esters will not exhibit short-term effects to fish up to the limit of water solubility.