Registration Dossier
Registration Dossier
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EC number: 208-859-5 | CAS number: 544-10-5
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of chlorinated alkanes on hepatic triglyceride secretion
- Author:
- Selan, F.M. and Evans, M.A.
- Year:
- 1 987
- Bibliographic source:
- Res. Comm. Chem. Pathol. Pharmacol., 55(2), 249-269, Feb. 1987
Materials and methods
- Principles of method if other than guideline:
- Specific test design.
Test material
- Reference substance name:
- 1-chlorohexane
- EC Number:
- 208-859-5
- EC Name:
- 1-chlorohexane
- Cas Number:
- 544-10-5
- Molecular formula:
- C6H13Cl
- IUPAC Name:
- 1-chlorohexane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
Administration / exposure
- Route of administration:
- other: oral, gavage
- Vehicle:
- other: corn oil
- Duration of treatment / exposure:
- Exposure period: 2 hour(s)
- No. of animals per sex per dose:
- 4
Results and discussion
Any other information on results incl. tables
In vivo, ID50 was apparently inversely related to the lipophilicity of the
compounds: those with the longer carbon chain and less chlorine substituents
were less inhibitory on TG release from the liver.
For 1-chlorohexane, the mean ID50 (after 2 h post-treatment) was high at 7.6 g/kg.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
