Registration Dossier
Registration Dossier
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EC number: 204-428-0 | CAS number: 120-82-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable documented publication
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- DOW Chem. Co (1977), Subchronic Toxicity study of inhaled|1.2.4-trichlorobenzene in rats, NTIS/OTS 84003A, Doc ID.|87821105
- Title:
- No information
- Author:
- Watanabe, P.G. et al. (1978): Toxicol. Appl. Pharmacol. 45,|332 - 333
Materials and methods
- Principles of method if other than guideline:
- Method: other: 26 females/10 males/dose group, interim kill at 0.5, 1, 2, 3 months, gross necropsies
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- IUCLID4 Test substance: other TS: purity: 99.6 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- 6 hours/day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 or 10 ppm (24 or 80 mg/m3)
Basis:
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: 2 to 4 months
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 3 ppm
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
