1,2,4-trichlorobenzene

Toxicity to other aquatic organisms

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to other aquatic vertebrates

Type of information:

other: EU Risk Assessment

Adequacy of study:

other information

Reliability:

other: EU Risk Assessment

Rationale for reliability incl. deficiencies:

other: No reliability is given as this is a summary entry for the EU RAR.

Principles of method if other than guideline:

EU Risk Assessment

GLP compliance:

not specified

EU Risk Assessment (2003):

 

Short-term toxicity to Tetrahymena pyriformis (freshwater aquatic protozoa), Tanytarsus dissmilis (chironomid midge) and Aplexa hypnorum (snail) was studied by Yoshioka et al. (1985) and Holcombe et al. (1987). They found EC50 values ranging from 0,91 mg/l (protozoa) to 3,16 mg/l (snail).

Executive summary:

EU Risk Assessment (2003):

 

Short-term toxicity to Tetrahymena pyriformis (freshwater aquatic protozoa), Tanytarsus dissmilis (chironomid midge) and Aplexa hypnorum (snail) was studied by Yoshioka et al. (1985) and Holcombe et al. (1987). They found EC₅₀ values ranging from 0,91 mg/l (protozoa) to 3,16 mg/l (snail).

Reference 2

Endpoint:

toxicity to other aquatic vertebrates

Type of information:

other: BUA report

Adequacy of study:

other information

Reliability:

other: BUA report

Rationale for reliability incl. deficiencies:

other: No reliability is given as this is a summary entry for the BUA report.

Principles of method if other than guideline:

BUA report

GLP compliance:

not specified

BUA report (1987):

 

In a test on Tetrahymena pyriformisan EC50 of 0,91 mg/l was determined after 24 h test duration (Yoshioka et al., 1985).

 

In a flow-through test on Branchiostoma caribaeum after 96 hours a LC0 of 1,5 mg/l and a LC100 of 10 mg/l was found. When 1,2,4-TCB was added to the test system via sediment after 10 days the following toxic endpoints were found: LC0 = 75 mg/kg, LC50 = 200 mg/kg and LC100 = 240 mg/kg (Clark et al., 1987).

 

In a test on teratogenicity 1,2,4-TCB showed an effected on the larval development of Artemia salina (Kerster and Schaeffer, 1983).

Executive summary:

BUA report (1987):

 

In a test on Tetrahymena pyriformisan EC₅₀ of 0,91 mg/l was determined after 24 h test duration (Yoshioka et al., 1985).

In a flow-through test on Branchiostoma caribaeum after 96 hours a LC₀ of 1,5 mg/l and a LC₁₀₀ of 10 mg/l was found. When 1,2,4-TCB was added to the test system via sediment after 10 days the following toxic endpoints were found: LC₀ = 75 mg/kg, LC₅₀ = 200 mg/kg and LC₁₀₀ = 240 mg/kg (Clark et al., 1987).

 

In a test on teratogenicity 1,2,4-TCB showed an effected on the larval development of Artemia salina (Kerster and Schaeffer, 1983).

Description of key information

For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".

 

Studies were performed in different test species (Tetrahymena pyriformisan, Branchiostoma caribaeum, Artemia salina, Tanytarsus dissmilis, Aplexa hypnorum), with varying exposure times and revealed following values:

EC50: 0.91 - 3.16 mg/L

LC0: 1.5 mg/L

LC100: 10 mg/L

 

BUA report (1987):
In a test on Tetrahymena pyriformisan EC50 of 0,91 mg/l was determined after 24 h test duration (Yoshioka et al., 1985).
In a flow-through test on Branchiostoma caribaeum after 96 hours a LC0 of 1,5 mg/L and a LC100 of 10 mg/L was found. When 1,2,4-TCB was added to the test system via sediment after 10 days the following toxic endpoints were found: LC0 = 75 mg/kg, LC50 = 200 mg/kg and LC100 = 240 mg/kg (Clark et al., 1987).
In a test on teratogenicity 1,2,4-TCB showed an effected on the larval development of Artemia salina (Kerster and Schaeffer, 1983).

EU Risk Assessment (2003):
Short-term toxicity to Tetrahymena pyriformis (freshwater aquatic protozoa), Tanytarsus dissmilis (chironomid midge) and Aplexa hypnorum (snail) was studied by Yoshioka et al. (1985) and Holcombe et al. (1987). They found EC50 values ranging from 0,91 mg/L (protozoa) to 3,16 mg/L (snail).