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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed source, valid collection of data
GLP compliance:
not specified
Type of method:
other: no data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
0.019 g/L
Temp.:
20 °C
Remarks on result:
other: The pH value was not reported.

pH was not reported.

Executive summary:

Roempp, 2009


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 19 mg/L at 20 °C. The pH value was not reported.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed scoure, valid collection af data
GLP compliance:
not specified
Type of method:
other: no data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
31.3 mg/L
Temp.:
25 °C
Remarks on result:
other: The pH value was not reported.

pH was not reported.

Executive summary:

HSDB, 2009


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 31.3 mg/L at 25 °C. The pH value was not reported.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed source, valid collection of data
GLP compliance:
not specified
Type of method:
other: no data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
37.8 mg/L
Temp.:
25 °C
Remarks on result:
other: The pH value was not reported.
Details on results:
this value is calculated from the value as cited in the literature (0.00379 mass%)

no further data on pH

Executive summary:

Lide, 2001


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 37.8 mg/L at 25 °C. The pH value was not reported.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed scoure, valid collection af data
GLP compliance:
not specified
Type of method:
other: na data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
ca. 0.04 g/L
Temp.:
20 °C
Remarks on result:
other: The pH value was not reported.
Executive summary:

Hommel, 1994


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 40 mg/L at 20 °C. The pH value was not reported.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed scoure, valid collection af data
GLP compliance:
not specified
Type of method:
other: no data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
0.03 g/L
Temp.:
20 °C
Remarks on result:
other: The pH value was not reported.
Executive summary:

Rippen, 1991


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 30 mg/L at 20 °C. The pH value was not reported.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed scoure, valid collection af data
GLP compliance:
not specified
Type of method:
other: no data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
45.3 mg/L
Temp.:
25 °C
Remarks on result:
other: The pH value was not reported.
Executive summary:

Miller, 1984


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 45.3 mg/L at 25 °C. The pH value was not reported.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed scoure, valid collection af data
GLP compliance:
not specified
Type of method:
other: no data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
34.6 mg/L
Remarks on result:
other: The temperature and pH value were not reported.
Executive summary:

EPA, 1985


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 34.6 mg/L. The temperature and pH value were not reported.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed scoure, valid collection af data
GLP compliance:
not specified
Type of method:
other: no data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
0.019 g/L
Temp.:
20 °C
Remarks on result:
other: The pH value was not reported.
Executive summary:

UBA, 1984


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 19 mg/L at 20 °C. The pH value was not reported.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
Principles of method if other than guideline:
secondary peer reviewed scoure, valid collection af data
GLP compliance:
not specified
Type of method:
other: no data
Specific details on test material used for the study:
analytical purity: not specified
Water solubility:
30 mg/L
Temp.:
25 °C
Remarks on result:
other: The pH value was not reported.
Executive summary:

Hooftman, 1982


The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 30 mg/L at 25 °C. The pH value was not reported.

Description of key information

The individual study reports (data from handbooks or collection of data and (QSAR)calculations) show some deficiencies with respect to the comprehensiveness of the experimental details. Therefore, a reliability of 1 or 2 and thus adequacy as key study was not assignable for any of the individual studies. Consequently, the studies were assigned a Klimisch score of 4 (according to guidance document R.4, ‘not assignable: studies or data […] which are only listed in short abstracts or secondary literature (books, reviews, etc.)). As the individual studies report values are in a similar range, collectively, these studies can be used to conclude on this endpoint and to satisfy the information requirement.


 


The water solubility of 1,2,4-trichlorobenzene has been determined in a series of experimental studies and ranges from 19 mg/L to 40 mg/L at a temperature of 20 °C. The mean value of 29.5 mg/L at 20 °C was chosen as key value for chemical safety assessment.


At a temperature of 25 °C, the water solubility is reported to be between 30 mg/L and 45.3 mg/L. The pH value was not reported.


 


Roempp, 2009
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 19 mg/L at 20 °C. The pH value was not reported.



HSDB, 2009
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 31.3 mg/L at 25 °C. The pH value was not reported.


 


Lide, 2001
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 37.8 mg/L at 25 °C. The pH value was not reported.



Hommel, 1994
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 40 mg/L at 20 °C. The pH value was not reported.



Rippen, 1991
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 30 mg/L at 20 °C. The pH value was not reported.



Miller, 1984
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 45.3 mg/L at 25 °C. The pH value was not reported.



EPA, 1985
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 34.6 mg/L. The temperature and pH value were not reported.



UBA, 1984
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 19 mg/L at 20 °C. The pH value was not reported.



Hooftman, 1982
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 30 mg/L at 25 °C. The pH value was not reported.

Key value for chemical safety assessment

Water solubility:
29.5 mg/L
at the temperature of:
20 °C

Additional information