Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 16 May 2008 and 02 July 2008.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
The work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
< -2.82
Temp.:
24.9 °C
pH:
7

Any other information on results incl. tables

Preliminary estimate

Approximate solubility in n-octanol: <1.20 x 10-2 g/l
Approximate solubility in water:       >10.2 g/l
Approximate Pow:   <1.18 x 10 -3
Log10 Pow:   <-2.93

Definitive test

The absorbance obtained for the standard, stock and sample solutions are shown in the following two tables:

Solution

Absorbance

Standard 5.05 mg/l

0.13508

Standard 5.07 mg/l

0.13106

Organic phase matrix blank

None detected

Sample 1

≤0.039209*

Sample 2

<0.039209*

Sample 3

<0.039209*

Sample 4

<0.039209*

Sample 5

<0.039209*

Sample 6

<0.039209*

 

Solution

Absorbance

Standard 10.1 mg/l

0.23696

Standard 16.1 mg/l

0.36283

Standard 20.1 mg/l

0.42816

Standard 20.1 mg/l

0.43168

Standard 24.1 mg/l

0.50047

Standard 30.2 mg/l

0.55823

Standard 40.2 mg/l

0.65444

Aqueous phase matrix blank

None detected

Sample 1

0.42759

Sample 2

0.44116

Sample 3

0.43542

Sample 4

0.42616

Sample 5

0.43592

Sample 6

0.44174

Stock solution A

0.42713

Stock solution B

0.42511


* see Section 9.6

The total weights (mg) and analysed concentration (mg/l) of the respective phases are shown in the following table:

 

Sample Number

Volume of water saturated

n-octanol (ml)

Volume of stock solution (ml)

Total Weight (mg)*

Organic Phase

Aqueous Phase

Analysed Concentration (mg/l)

Weight (mg)†

Analysed Concentration (mg/l)

Weight (mg)†

pH

1

70

70

139

≤2.98

≤0.209

2.00 x 103

140

6.7

2

70

70

139

2.98

0.209

2.08 x 103

146

6.7

3

40

80

159

2.98

0.119

2.04 x 103

164

6.8

4

40

80

159

2.98

0.119

1.99 x 103

159

6.8

5

80

40

79.5

2.98

0.238

2.05 x 103

81.9

6.9

6

80

40

79.5

2.98

0.238

2.08 x 103

83.3

6.9

pH of n-octanol saturated water:           6.9
pH of stock solution:                             7.1
Temperature:                                        24.9 ± 0.5°C

The partition coefficient determined for each sample is shown in the following table:

 

Sample Number

n-octanol/water Volume Ratio

Partition Coefficient

Log10 Pow

Mean Partition Coefficient

1

1:1

≤1.49 x 10-3

≤-2.83

≤1.49 x 10-3

2

1.43 x 10-3

-2.84

3

1:2

1.46 x 10-3

-2.84

1.50 x 10-3

4

1.50 x 10-3

-2.82

5

2:1

1.46 x 10-3

-2.84

1.46 x 10-3

6

1.43 x 10-3

-2.85


* From analysis of the stock solution

† From analysis of the respective phase

Mean Pow  : 1.50 x 10-3                       log10Pow : -2.82

Validation

The linearity of detector response with respect to concentration was assessed over the nominal concentration range of 0 to 10 mg/l for the organic solutions. This was satisfactory, with a correlation coefficient of 0.999 being obtained.

Discussion

Substances having a log10 Pow of greater than 3 are regarded as having the potential to bioaccumulate in the environment.

The test was carried out using unadjusted n-octanol saturated water, at ~ pH 7 (as recommended for salts).

No test material was detected in any of the organic samples.  The limit value was taken for the sample with the highest baseline absorbance at the analytical wavelength (Sample 1).

Conclusion

The partition coefficient of the test material has been determined to be less than 1.50 x 10-3 at 24.9 ± 0.5°C, log10 Pow -2.82.

Applicant's summary and conclusion

Conclusions:
The partition coefficient of the test material has been determined to be less than 1.50 x 10-3 at 24.9 ± 0.5°C, log10 Pow <-2.82.
Executive summary:

The determination for substance NDS-Li in project number 1307 -0447 was carried out using the shake-flask method, Method A8 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC). The partition coefficient of the test material has been determined to be less than 1.50 x 10-3 at 24.9 ± 0.5°C, log10 Pow