Registration Dossier
Registration Dossier
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EC number: 224-832-0 | CAS number: 4511-42-6
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-09-03 to 2009-10-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study, but no guideline followed
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): LL Lactide
- Batch no: 0902000694
- Purity 100 %
- Expiration date of the lot/batch: 2010-02-10
- Stability under storage conditions: stable
- test substance storage: at room temperature in the dark
- sample density: 1.33 g/cm3 - Medium:
- other: sunflower oil
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, well dispersed
- Medium:
- other: silicone oil
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, well dispersed
- Medium:
- other: kerosene
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, but poor dispersion stability
- Medium:
- toluene
- Solubility:
- other: soluble
- Conclusions:
- In conclusion, it can be stated that LL-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.
- Executive summary:
The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. LL lactide is insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene.
Reference
Description of key information
The solubility of the test item in organic solvents was assessed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. LL lactide is insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene.
Key value for chemical safety assessment
Additional information
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