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Toxicological information

Carcinogenicity

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Description of key information

The available data suggests that C16-C18 TMAC is not carcinogenic to humans and does not require classification for this endpoint according to EC (67/548/EEC) and CLP (EC 1272/2008) criteria. This conclusion is based on negative results from genotoxicity studies. Also, repeated dose toxicity studies provided no evidence of carcinogenicity (overall low toxicity together with the absence of any hyperplastic or pre-neoplastic lesions in any organs). This is further supported by the absence of alerts for carcinogenic activity as per the ISS rule of the OECD QSAR Toolbox v.2.3. 

Key value for chemical safety assessment

Additional information

The available data suggests that C16-C18 TMAC is not carcinogenic to humans and does not require classification for this endpoint according to EC (67/548/EEC) and CLP (EC 1272/2008) criteria. This conclusion is based on negative results fromgenotoxicity studies. Also, repeated dose toxicity studies provided no evidence of carcinogenicity (overall low toxicity together with the absence of any hyperplastic or pre-neoplastic lesions in any organs). This is further supported by the absence of alerts for carcinogenic activity as per the ISS rule of the OECD QSAR Toolbox v.2.3.

Justification for classification or non-classification

No classification is required according to EC (67/548/EEC) and CLP criteria (EC 1272/2008).