Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 484-460-1 | CAS number: 37859-55-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across from an analogue substance for which a guideline study (Klimish =1) is available.
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 782 mg/kg bw
- Based on:
- other: Read-across from an analogue substance.
- Remarks on result:
- other: (read-across from an analogue for which LD50 > 2000 mg/kg bw)
- Interpretation of results:
- other: Not classified according to CLP criteria.
- Conclusions:
- Based on the read-across approach from the analogue substance OS1200, the LD50 of OS1600 to rats was determined to be greater than 1782 mg/kg bw.
- Executive summary:
An acute dermal toxicity study was performed on the analogue substance OS-1200 according to EU Method B.3. Based on these results, the read-across approach was applied and the acute lethal dermal dose of OS1600 to rats was determined to be greater than 1782 mg/kg bw.
The data matrix is included in the reporting format attached.
The results from the read-across approach are expressed (calculated) on the basis of the molecular weight of OS1600 and OS1200 since the basic structures of the target and source substances are the same. No other adaptation is necessary.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
