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Adsorption / desorption

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Endpoint:
adsorption / desorption: screening
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Reason / purpose:
data waiving: supporting information
Qualifier:
according to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
Qualifier:
according to
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. certificate)
Conclusions:
The adsorption coefficient of the test substance cannot be determined due to the quick hydrolysis of the test substance (half life time < 4 minutes)
Executive summary:

The adsorption coefficient of the test substance cannot be determined due to the quick hydrolysis of the test substance (half life time < 4 minutes)

Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Conducted with the main hydrolysis product= MPKO.
Qualifier:
according to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
not specified
Qualifier:
according to
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Deviations:
not specified
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge
Test temperature:
35 +- 1°C
Details on study design: HPLC method:
Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA) Detector: Dual lambda Absorbance Detector 2487 (Waters) Column: 150 mm x 4.6 mm id. Hypersil BDS-CN; dp = 5 microm (Thermo, San Jose, CA?, USA) Column temperature: 35 +- 1 °C Mobile phase neutral pH: 30/70 (v/v) methanol/water Flow: 1 ml/min Injection volume: 10 microL UV detection: 210 nm
Analytical monitoring:
yes
Key result
Type:
Koc
Value:
< 20.9 dimensionless
Temp.:
35 °C
Key result
Type:
log Koc
Value:
< 1.32 dimensionless
Temp.:
35 °C
Details on results (HPLC method):
In the chromatogram of the test solution, one test substance peak was observed at a retention time of 2.6 minutes. Under the same analytical conditions, the retention time of phenol (log Koc = 1.32) was 3.1 minutes. Hence, it was concluded that the log Koc of the test substance was < 1.32 (Koc < 20.9).

pKa value for an acidic group in the molecular structure of the test substance was calculated using the Perrin calculation method:

RRC=NOH, pKa 12,49.

Validity criteria fulfilled:
yes
Conclusions:
The Koc and log Koc value of MPKO at neutral pH were determined to be <20.9 and <1.32 respectively.
Executive summary:

The adsorption coefficient (log Koc) of MPKO was determined by means of HPLC in accordance with OECD Guideline 121 and EU Method C19. In the chromatogram of the test solution, one test substance peak was observed at a retention time of 2.6 minutes. Under the same analytical conditions, the retention time of phenol (log Koc = 1.32) was 3.1 minutes. Hence, it was concluded that the log Koc of the test substance was < 1.32 (Koc < 20.9). The Koc and log Koc value of MPKO at neutral pH were determined to be < 20.9 and <1.32 respectively.

Description of key information

OS1600 shows quick hydrolysis in aqueous solutions. Therefore the adsorption coefficient cannot be determined. However, the log Koc was determined for MPKO, the hydrolysis product of OS1600. It was determined to be < 1.32.

Key value for chemical safety assessment

Koc at 20 °C:
20.9

Additional information

Data waiving (study not technically feasible): The adsorption coefficient of the test substance cannot be determined due to the quick hydrolysis of the test substance (half life time < 4 minutes).

Supporting study: The adsorption coefficient (log Koc) of MPKO was determined by means of HPLC in accordance with OECD Guideline 121 and EU Method C19 (GLP study). The Koc and log Koc value of the test substance at neutral pH were determined to be < 20.9 and <1.32 respectively.

[LogKoc: 1.32]