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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

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Endpoint:
water solubility
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)
Reason / purpose for cross-reference:
data waiving: supporting information
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Key result
Remarks on result:
not determinable
Remarks:
The test substance shows quick hydrolysis in aqueous solutions (half life time < 4 minutes) therfore water solubility cannot be determined.
Details on results:
The test substance shows quick hydrolysis in aqueous solutions (half life time < 4 minutes) therfore water solubility cannot be determined.
Conclusions:
The water solubility of the test substance cannot be determined due to the quick hydrolysis of the test substance (half life time < 4 minutes)
Executive summary:

The water solubility of the test substance cannot be determined due to the quick hydrolysis of the test substance (half life time < 4 minutes)

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Conducted with the main hydrolysis product= MPKO.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
ca. 34.7 g/L
Temp.:
19.8 °C
pH:
ca. 7.4
Conclusions:
The water solubility of the test substance was 34.7 g/L at 19.8 ± 0.5°C and a pH of 7.4.
Executive summary:

The flask method was chosen for the determination of the water solubility of MPKO in accordance with OECD Guideline 105 and EU Method A.6. The water solubility of the test substance at 19.8 ± 0.5°C was 34.7 g/L. The pH of the aqueous samples was 7.4.

Description of key information

The water solubility of the test substance cannot be determined due to the quick hydrolysis of the test substance (half life time < 4 minutes). The water solubility of MPKO, the hydrolysis product of OS1600, was determined to be 34.7 g/L at 19.8°C and pH of 7.4.

Key value for chemical safety assessment

Water solubility:
34.7 g/L
at the temperature of:
19.8 °C

Additional information

Data waiving (study technically not feasible): The test substance hydrolyses quickly (half life time < 4 minutes) and therefore, the partition coefficient cannot be determined.

Supporting study: The water solubility of the analogue substance MPKO was determined using the flask method in accordance with OECD Guideline 105 and EU Method A.6. The water solubility was 34.7 g/L at 19.8 ºC and pH of 7.4.