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EC number: 202-773-1
CAS number: 99-62-7
An acute oral toxicity study was conducted with two groups of four male
and four female rats. Animals were fasted overnight prior to
administration of the test substance. Dose levels were 1600 and 3200
mg/kg. At study start, animals weighed 170 to 226 grams. The test
substance was administered neat by stomach tube. Immediately after
dosing, all animals appeared slightly weak. Slight to moderate weakness
and roughened hair coats were noted at one hour, and slight weakness and
rough hair coats were noted at two hours after dosing. By four hours
after administration of the test substance, no abnormal clinical signs
were observed in either sex at either dose level. No further abnormal
clinical signs were observed at any time during the fourteen-day
observation period. All animals gained weight during the study. No
necropsies were conducted. Based on the results of this study, the acute
oral LD50 was greater than 3200 mg/kg in male and female rats. This
study was conducted between February 5 and March 1, 1982.
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