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Diss Factsheets

Administrative data

Description of key information

NOAEL = 100000 ppm (188000 mg/m3) air

Key value for chemical safety assessment

Additional information

A traditional OECD 403 acute toxicity test was not available for the test substance. However, a repeated dose study exceeded the exposure and observation times recommended in the OECD 403 guideline. The repeated dose study provides reliable results appropriate for evaluation of acute toxicity. There were no deaths in rats exposed repeatedly to 100000 ppm (188000 mg/m3) for 7 hours/day, 5 days/week for 6 weeks. Therefore, the 4-hour inhalation LC50 in rats is >100000 ppm.  

 

This substance is a gas, and tests to evaluate dermal and oral systemic toxicity were not feasible.

 

Dose Descriptor: NOAEL for significant systemic effects resulting from acute inhalation exposure was 100000 ppm (188000 mg/m3)

Justification for classification or non-classification

Based on the rat 4-hour LC50 of >100000 ppm (188000 mg/m3), the substance does not need to be classified for acute toxicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.