Registration Dossier
Registration Dossier
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EC number: 209-676-3 | CAS number: 590-28-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- ANALOGUE APPROACH JUSTIFICATION
Read-across from sodium cyanate was performed. In aqueous solution cyanate salts dissociate very quickly to cyanate ion and the respective alkali metal ion. It is not expected that Na+ or K+ contribute to the partition coefficient. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 20 °C
- pH:
- 6
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-12-10 to 2008-12-11
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- EC-No. 440/2008
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 20 °C
- pH:
- 6
- Conclusions:
- A log Pow of 0.127 was measured. This value lies outside the range of the recommended reference items. The log Pow of the test item Sodium cyanate is stated as < 0.3.
- Executive summary:
A log POW of 0.127 was measured (HPLC-Method). This value lies outside the range of the recommended reference items. Therefore, the log POW of the test item Sodium cyanate is stated as < 0.3.
Referenceopen allclose all
Description of key information
No study is available for potassium cyanate. Read across from sodium cyanate was performed instead. In aqueous solution cyanate salts dissociate very quickly to cyanate ion and the respective alkali metal ion. It is not expected that Na+ or K+ contribute to the partition coefficient.
A log Pow of 0.127 was measured (HPLC-Method). This value lies outside the range of the recommended reference items. Therefore, the log Pow of the test item sodium cyanate is stated as < 0.3.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.3
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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