Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-589-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Read across study
- Justification for type of information:
- Refer to the section 13 of the IUCLID dataset for details on the read across justification. The short term toxicity study to fish with the read across substance is considered sufficient to fulfil the information requirements.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Environment Canada method, Biological Test Method: Acute Lethality Test Using Rainbow Trout, EPS 1/RM/9 (EC 1990/1996)
- Deviations:
- no
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: not specified, sampling at test initiation (0 h) and test end (96 h)
- Sampling method: no data
- Sample storage conditions before analysis: no data - Vehicle:
- no
- Details on test solutions:
- No data
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Test organisms:
- Common name: rainbow trout
- Strain: no data
- Source: no data
- Age at study initiation (mean and range, SD): no data
- Length at study initiation (length definition, mean, range and SD): mean fish length = 3.9 or 3.6 cm
- Weight at study initiation (mean and range, SD): mean fish weight = 0.49 or 0.38 g
- Method of breeding: no data
- Feeding during test: not applicable, no feeding during test, fish were starved for at least 12 h prior to test initiation - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 14 mg/L as CaCO3 (measured by EDTA titration)
- Test temperature:
- 15±1°C
- Nominal and measured concentrations:
- Nominal: control and five test concentrations
Measured: 96-110% of nominal at test initiation and test end - Details on test conditions:
- Test system:
- Test vessel: no further details
- Type (delete if not applicable): open (covered with plexiglass sheet
- Material, size, headspace, fill volume: plastic-lined glass aquarium (12 or 15 L)
- Aeration: 30 minutes prior to addition of the fish and during test
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.33 or 0.32 g/L
Test medium / test parameters
- Source/preparation of dilution water: dechlorinated and hardened Vancouver city tap water
Other test conditions:
- Adjustment of pH: no data
- Photoperiod: no data
- Light intensity: no data
Effect parameters observed (with observation intervals if applicable) :
- mortality
- behaviour - Reference substance (positive control):
- yes
- Remarks:
- Phenol
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 460 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- analytically verified
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 250-625 mg/L
- Details on results:
- - Mortality of control: 0%
- Other adverse effects control: none of control fish displayed loss of equilibrium or atypical swimming behaviour.
- Abnormal responses: no
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Other: Reference toxicant (positive control) tests were conducted with phenol with each batch of fish used, and the resulting LC50s were within two standard deviations of previous tests. - Reported statistics and error estimates:
- Binomial option in “Bioassay Program”, a Lotus Notes-based application which implements a BASIC computer program obtained from Environment Canada that is based on calculations in Stephan, 1977, Methods for Calculating an LC50, in: Aquatic Toxicology and Hazard Evaluation (ASTM STP 634), Mayer and Hamelink (eds.), ASTM, Philadelphia, PA, pp. 65-84.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the 96 h LC50 of the substance to rainbow trout was determined to be 460 mg a.i./L.
- Executive summary:
A study was conducted to determine the short-term toxicity of the read-across substance 2,2’-iminodiethanol (diethanolamine) to fish according to the Environment Canada method, Biological Test Method: Acute Lethality Test Using Rainbow Trout, EPS 1/RM/9 (EC 1990/1996). Rainbow trout were exposed to the test substance at five concentrations for a period of 96 h under static test conditions. A negative control group with fish not exposed to the test substance as well as a positive control with phenol were included in the experiment. The number of mortalities and any sub-lethal effects of exposure in each test and control vessel were determined throughout the experiment. No mortality was observed during the experiment. Under the study conditions, the 96 h LC50 of the substance to rainbow trout was determined to be 460 mg a.i./L (Petroleum Technology Alliance Canada, 2006).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
A study was conducted to determine the acute toxicity of the read-across substance phosphoric acid, mono- and di-C12-18-(even numbered)-alkyl esters, sodium salts (mono- and di- C12-18 PSE, Na+) to fish according to OECD Guideline 203 and EU Method C.1, in compliance with GLP. Seven fish (Cyprinus carpio) per group were exposed to a control (medium alone) and to 100% of the saturated solution. The total exposure period was 96 h and the experiment was conducted under static conditions. Due to the complex nature of the test substance, specific analyses proved to be difficult to obtain and it was decided to analyse the Total Organic Carbon (TOC) concentration as a surrogate measure. Samples for TOC concentrations were taken at the start and after 24 and 96 h of exposure. The TOC analysis performed on samples taken from 100% of the saturated solution should be regarded as indicative because of the low carbon concentrations. Effect parameters were based on the percentages of the saturated solution prepared at a loading rate of 100 mg/L. No mortality or clinical effects were observed at the limit concentration and in the control during the test period. The responses recorded in this test allowed for reliable determination of an LL50. The study met the acceptability criteria prescribed by the study plan and was considered valid. Under the study conditions, the 96 h LL50 of the substance in Cyprinus carpio was determined to be greater than 100 mg/L (Bouwman, 2017).
A study was conducted to determine the short-term toxicity of the read-across substance 2,2’-iminodiethanol (diethanolamine) to fish according to the Environment Canada method, Biological Test Method: Acute Lethality Test Using Rainbow Trout, EPS 1/RM/9 (EC 1990/1996). Rainbow trout were exposed to the test substance at five concentrations for a period of 96 h under static test conditions. A negative control group with fish not exposed to the test substance as well as a positive control with phenol were included in the experiment. The number of mortalities and any sub-lethal effects of exposure in each test and control vessel were determined throughout the experiment. No mortality was observed during the experiment. Under the study conditions, the 96 h LC50 of the substance to rainbow trout was determined to be 460 mg a.i./L (Petroleum Technology Alliance Canada, 2006).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.