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EC number: 946-448-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
They key studies for dermal irritation are based on the read across substance Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 1-aminopropane-2-ol. To determine the potential skin effects of Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with isopropanolamine, the substance was tested in two in vitro studies with the use of reconstructed human epidermis models (EPISKINTM). The principle of the assays is based on the measurement of cytotoxicity in the human epidermal cultures following topical exposure to the test material, with the MTT reduction assay. Both test gave negative results, suggesting that the substance has no skin corrosive or irritating properties.
A key study for eye irritation (Liggett and Parcell 1986A) examined the potential of the read across substance (Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts) to cause irritation to eyes. Groups of three rabbits had 0.1 ml of test substance placed in each of their eyes. In one group, the eyes were not rinsed. In the second group, the eyes were rinsed after 4 seconds of exposure. In the third group, the eyes were rinsed after 30 seconds of exposure. Observations were made one hour and 1, 2, 3, 4, 7, 14, and 21 days after exposure. Severe irritation was noted in the animals whose eyes were not rinsed. This irritation was not resolved in one of these animals at the end of 21 days. Irritation was also seen in the animals rinsed after 30 seconds, although the irritation was not as severe, and the effects were fully reversible within 14 days. Mild irritation was seen in the animals rinsed after 4 seconds. These effects were fully reversible within 7 days. Since OECD guideline 405 for eye irritation studies calls for an exposure of at least 24 hrs, the results for unrinsed eyes were used for classification. According to these results, the test substance is a Category 1 eye irritant because it caused damage that was not reversible within 21 days (H318: Causes serious eye damage).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- Three-dimensional reconstructed human epidermis- EPISKIN model kit purchased from SkinEthic Laboratories (Nice, France).
- Type of coverage:
- other: not applicable
- Controls:
- other: not applicable
- Amount / concentration applied:
- not applicable
- Duration of treatment / exposure:
- 3, 60 and 240 min
- Details on study design:
- Pre-test: Test MTT reduction by the test material: 50 ul test material + 2.2 ml 0.3 mg/ml MTT solution incubated for 3 h. The blue colour indicates reduced MTT.
MAIN TEST
DAY 1-Application of test item
Exposure: 3, 60 and 240 min
Amount applied: 50 ul
Negative control: 50 ul of 0.9% w/v sodium chloride
Positive control: 50 ul glacial acetic acid
Washing: PBS with Ca++ and Mg++
MTT solution was applied: 2.2 ml of 0.3 mg/ml per well, incubation followed for 3 h ± 5 min
Biopsy of the epidermis was performed. The tissue was then transfered in micro tubes with 850 ul acidified isopropanol.
DAY 2-Absorbance/Optical Density
at 540 nm with Anthos 2001 microplate reader - Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 240 minutes
- Value:
- 66.5
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 60 minutes
- Value:
- 83.8
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 3 minnutes
- Value:
- 87.9
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this in vitro test MARLON AMI 80, and hence benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with isopropanolamine (1:1), are not corosive to the skin.
- Executive summary:
The skin corrosion potential of MARLON AMI 80 (78% benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with isopropanolamine (1:1) in 1,2-propylene glycol) was examined in this in vitro test with the EPISKINTMreconstructed human epidermis model. Exposure to the substance lasted 3, 60, and 240 minutes.The principle of the assay was based on the measurement of cytotoxicity in the human epidermal cultures following topical exposure to the test item, with the MTT reduction assay.
The relative mean viability of the test item treated tissues was 66.5, 83.8 and 87.9%, after the exposure periods of 240 60, and 3 minutes, respectively. Therefore, MARLON AMI 80 is not corrosive to the skin. Based on this result, benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with isopropanolamine (1:1) shall not be considered as skin corrosive.
The study is considered acceptable based on the quality criteria. The test was performed according to the OECD Guidelines for the Testing of Chemicals No. 431 “In VitroSkin Corrosion” (adopted April 2004).
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- Three-dimensional reconstructed human epidermis- EPISKIN model kit purchased from SkinEthic Laboratories (Lyon, France).
- Type of coverage:
- other: not applicable
- Controls:
- other: not applicable
- Amount / concentration applied:
- not applicable
- Duration of treatment / exposure:
- 15 min
- Details on study design:
- Test MTT reduction by the test material: 10 ul test material + 2 ml 0.3 mg/ml MTT solution incubated for 3 h. The blue colour indicates reduced MTT.
MAIN TEST
DAY 1-Application of test item
Exposure: 15 min
Amount applied: 10 ul
Negative control: 10 ul DPBS
Positive control: 10 ul 5% w/v SDS
Washing: DPBS with Ca++ and Mg++
Post-exposure incubation: 42 h
DAY 3-MTT Loading/Formazan Extraction
Plate shaker: 15 min
MTT solution: 2 ml of 0.3 mg/ml per well
Incubation: 3 h
Biopsy of the epidermis was performed. The tissue was then transfered in micro tubes with 500 ul acidified isopropanol and refrigerated till day 6.
DAY 6-Absorbance/Optical Density
at 540 nm with Anthos 2001 microplate reader - Irritation / corrosion parameter:
- % tissue viability
- Value:
- 60
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this in vitro test MARLON AMI 80, and hence, benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with isopropanolamine (1:1) are not skin irritants.
- Executive summary:
The skin irritation potential of MARLON AMI 80 (78% benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with isopropanolamine (1:1) in 1,2-propylene glycol) was examined in this in vitro test withthe EPISKINTMreconstructed human epidermis model. Exposure to the substance lasted 15 minutes and it was followed by a post-exposure incubation period of 42 hours. The principle of the assay was based on the measurement of cytotoxicity in the human epidermal cultures following topical exposure to the test item, with the MTT reduction assay.
The relative mean viability of the test item treated tissues was 60.6% after the15-Minute exposure period and hence, MARLON AMI 80 is not a skin irritant. Based on this result, benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with isopropanolamine (1:1) shall not be considered a skin irritant.
The study is considered acceptable based on the quality criteria. The test was performed according to the OECD Guidelines for the Testing of Chemicals No. 439 “In Vitro Skin Irritation” (adopted 22 July 2010).
Referenceopen allclose all
Table 1: Mean OD540 Values and Viabilities for the Negative Control Item, Positive Control Item and Test Item
Item |
Exposure Period |
Mean OD540 of duplicate tissues |
Relative mean viability (%) |
Negative Control Item |
240 min |
0.173 |
100 |
Positive Control Item |
240 min |
0.033 |
19.1 |
Test Item |
240 min |
0.115 |
66.5 |
60 min |
0.145 |
83.8 |
|
3 min |
0.152 |
87.9 |
Table 1: Mean OD540Values and Percentage Viabilities for the Negative Control Item, Positive Control Item and Test Item
Item |
OD540 of tissues |
Mean OD540 of triplicate tissues |
± SD of OD540 |
Relative individual tissue viability (%) |
Relative mean viability (%) |
± SD of Relative mean viability (%) |
Negative Control Item |
0.811 |
0.821 |
0.012 |
98.8 |
100 |
1.5 |
0.835 |
101.7 |
|||||
0.817 |
99.5 |
|||||
Positive Control Item |
0.084 |
0.105 |
0.027 |
10.2 |
12.8 |
3.4 |
0.136 |
16.6 |
|||||
0.095 |
11.6 |
|||||
Test Item |
0.530 |
0.497 |
0.062 |
64.6 |
60.6 |
7.5 |
0.535 |
65.2 |
|||||
0.426 |
51.9 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 24, 1986-May 12, 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Rabbits and Buckmasters
- Age at study initiation: 9-13 weeks
- Weight at study initiation: 2.1-3.1 kg
- Housing: individually housed in metal cages, identified by aluminum ear tags
- Diet (e.g. ad libitum): SDS Standard Rabbit Diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 degree C
- Humidity (%): 30-70
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark
IN-LIFE DATES: From: March 24, 1986 To: May 12, 1986 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL aliquot of P-500 N-Na
- Duration of treatment / exposure:
- For three rabbits the eyelids were then gently held together for one second before releasing.
For three other rabbits the eyes were irrigated with water for 5 minutes following a 4-second exposure.
For the remaining three rabbits the eyes were irrigated for 5 minutes following a 30-second exposure. - Observation period (in vivo):
- Eyes were examined after 1 hour and 1, 2, 3, 4, 7, 14 and 21 days after exposure.
- Number of animals or in vitro replicates:
- 9
- Details on study design:
-
SCORING SYSTEM: Draize scale - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 1.75
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: not rinsed
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: rinse after 4 seconds
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 1.06
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: rinsed after 30 seconds
- Irritant / corrosive response data:
- The following results were noted:
1) Three animals without any rinsing: averaged irritation scores (24, 48, 72 hours) for each animal: cornea 2.3, 1.7, 2; iris: 1.3, 0, 0; conjunctivae redness: 3, 1.7, 2; conjunctivae chemosis: 3, 2, 2. In the first animal the effects were persistent at day 21.
2) Three animals with rinsing for five minutes following a 30 second exposure: averaged scores: cornea 0.7, 1, 1.3; iris: 0, 0.7, 0.3; conjunctivae redness: 1.7, 2, 1.3; conjunctivae chemosis: 2, 1.3, 2. The eyes were normal 7 or 14 days after instillation.
3) Three animals with rinsing for five minutes following a 4 second exposure: averaged scores: cornea 0.7, 2.3, 0.7; iris: 0, 0, 0; conjunctivae redness: 1.7, 1.7, 1; conjunctivae chemosis: 1.3, 2, 1. The eyes were normal 7 days after instillation.
Findings lead to a definition of irritating for LAS at 47% applied without rinsing, irritating (even if with lower effects, mainly as cornea opacity and conjunctivae redness) with rinsing after 30 second of exposure, and not irritating with rinsing after 4 second of exposure. - Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- When not rinsed, damage to the eyes due to the test substance was not reversed within 21 days. According to EU GHS guidelines the test substance is a category 1 eye irritant.
- Executive summary:
This study examined the potential of the test substance to cause irritation to eyes. Groups of three rabbits had 0.1 ml of test substance placed in each of their eyes. In one group, the eyes were not rinsed. In the second group, the eyes were rinsed after 4 seconds of exposure. In the third group, the eyes were rinsed after 30 seconds of exposure. Observations were made one hour and 1, 2, 3, 4, 7, 14, and 21 days after exposure. Severe irritation was noted in the animals whose eyes were not rinsed. This irritation was not resolved in one of these animals at the end of 21 days. Irritation was also seen in the animals rinsed after 30 seconds, although the irritation was not as severe, and the effects were fully reversible within 14 days. Mild irritation was seen in the animals rinsed after 4 seconds. These effects were fully reversible within 7 days. Since OECD guideline 405 for eye irritation studies calls for an exposure of at least 24 hrs, the results for unrinsed eyes were used for classification. According to these results, the test substance is a category 1 eye irritant because it caused damage that was not reversible within 21 days.
Reference
Results of Eye Irritation Study: No Rinsing
Hours |
Days |
||||||||
Animal |
1 |
24 |
48 |
72 |
4 |
7 |
14 |
21 |
|
1 |
Cornea |
2 |
1 |
2 |
4 |
3B |
3B |
3BC |
3BC |
Iris |
0 |
1 |
1 |
2 |
1 |
1 |
1 |
0 |
|
Conjunctiva - Erythema |
1 |
3 |
3 |
3 |
3 |
3 |
2 |
1 |
|
Conjunctiva - Chemosis |
2 |
3 |
3 |
3 |
3 |
2 |
2 |
1 |
|
2 |
Cornea |
1 |
1 |
2 |
2 |
2 |
1 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
Conjunctiva - Erythema |
1 |
1 |
2 |
2 |
1 |
0 |
0 |
||
Conjunctiva - Chemosis |
1 |
2 |
2 |
2 |
1 |
0 |
0 |
||
3 |
Cornea |
1 |
2 |
2 |
2 |
2 |
1 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
||
Conjunctiva - Erythema |
1 |
2 |
2 |
2 |
2 |
1 |
0 |
||
Conjunctiva - Chemosis |
1 |
2 |
2 |
2 |
2 |
0 |
0 |
Results of Eye Irritation Study: Rinsing after 4 Seconds
Hours |
Days |
||||||
Animal |
1 |
24 |
48 |
72 |
4 |
7 |
|
1 |
Cornea |
0 |
0 |
1 |
1 |
1 |
0 |
Iris |
0 |
0 |
0 |
0 |
1 |
0 |
|
Conjunctiva - Erythema |
1 |
2 |
2 |
1 |
2 |
0 |
|
Conjunctiva - Chemosis |
2 |
2 |
1 |
1 |
1 |
0 |
|
2 |
Cornea |
0 |
2 |
3 |
2 |
0 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctiva - Erythema |
1 |
2 |
2 |
1 |
2 |
0 |
|
Conjunctiva - Chemosis |
2 |
2 |
2 |
1 |
1 |
0 |
|
3 |
Cornea |
0 |
1 |
0 |
1 |
1 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctiva - Erythema |
1 |
1 |
1 |
1 |
2 |
0 |
|
Conjunctiva - Chemosis |
2 |
1 |
1 |
1 |
1 |
0 |
Results of Eye Irritation Study: Rinsing after 30 Seconds
Hours |
Days |
|||||||
Animal |
1 |
24 |
48 |
72 |
4 |
7 |
14 |
|
1 |
Cornea |
0 |
1 |
0 |
D |
D |
1 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctiva - Erythema |
1 |
2 |
2 |
1 |
1 |
1 |
0 |
|
Conjunctiva - Chemosis |
2 |
1 |
1 |
0 |
0 |
0 |
0 |
|
2 |
Cornea |
0 |
1 |
1 |
1 |
2 |
0 |
|
Iris |
0 |
0 |
1 |
1 |
0 |
0 |
||
Conjunctiva - Erythema |
1 |
2 |
2 |
2 |
2 |
0 |
||
Conjunctiva - Chemosis |
2 |
1 |
2 |
1 |
1 |
0 |
||
3 |
Cornea |
0 |
1 |
2 |
1 |
2A |
2AB |
0 |
Iris |
0 |
0 |
0 |
1 |
1 |
1 |
0 |
|
Conjunctiva - Erythema |
1 |
1 |
1 |
2 |
2 |
2 |
0 |
|
Conjunctiva - Chemosis |
2 |
2 |
2 |
2 |
1 |
1 |
0 |
A - Loss of Corneal Epithelium
B - Vascularization
C - Pannus
D - Dulling of the Cornea
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
Skin Irritation
Two in vitro tests were performed in order to assess the skin corrosive/irritating potential of LAS MIPA. Both studies gave a negative result, and hence the substance is not irritating to the skin.
In a supporting key study for dermal irritation (Liggett and Parcell 1986) examined the potential for the read across substance (Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts) to cause dermal irritation. Three rabbits were exposed to 0.5 ml of the test substance dermally for 4 hrs on clipped skin under a gauze pad held in place by an adhesive dressing. Examination of the treated skin was made approximately 30 minutes after removal of the patch and daily through 14 days. Grading and scoring of the dermal reactions was performed using the standard numerical scoring system. Irritation was noted in all animals at the first observation (maximum score of 2). Symptoms worsened, and desquamation, necrosis, and hyperkeratinization was noted by day 4. Symptoms resolved in one animal by day 12, but in the other two animals, symptoms were seen through the end of the observation period. The primary dermal irritation index was 2.17. The test substance is considered a Category 2 irritant according to CLP Regulation based on persistent irritation (H315: Causes skin irritation).
In an additional supporting study, MIPA was considered corrosive to skin. This data point is not considered relevant for the classification of the registered substance and it supported by in vitro data on Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 1-aminopropane-2-ol.
Eye Irritation
In eyes, administration of Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts resulted in severe irritation in the animals whose eyes were not rinsed and the effect was not resolved by day 21. Milder irritation was observed in animals that had the test substance rinsed from their eye after 4 or 30 seconds, and effects seen in these rinsed animals were reversible within 7 or 14 days. Based on the irreversible irritation observed in the unrinsed animals, Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts is considered a Category 1 eye irritant.
In a supporting study, MIPA was also considered corrosive to eyes.
In a final supporting study, Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 1-aminopropane-2-ol was tested an in vitro eye irritation test performed with the use of the SkinEthic Human Corneal Epithelium model. In that study the substance was considered an irritant. However, since the test is not so far officially accepted for regulatory purposes, it is proposed that the test material is classified as damaging to the eye similar to Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts.
Justification for classification or non-classification
No classification for skin irritation is based on 2 in vitro dermal studies on Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 1-aminopropane-2-ol, while a Category 1 Eye Irritant classification is based on results from an in vivo study on Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts.
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