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Diss Factsheets
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EC number: 701-177-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
The chemical safety assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to investigate further the toxicity to sediment organisms.
Key value for chemical safety assessment
Additional information
N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) has a log Kow of ≥3.5≤4.2 at 20°C (EU A.8, HPLC method) and a log Koc of 1.93 – 3.37 (pH 4 – pH 9, Franco, Fu and Trapp). Thus, the potential to adsorb or bind onto sediment is expected to be low to moderate. According to the Guidance on information requirements and chemical safety assessment, R.7b (ECHA, 2017) the equilibrium partitioning method (EPM) can be applied as a first screen to derive the PNEC sediment, in order to conduct a screening risk assessment for the sediment compartment (PEC/PNECsed). As the environmental exposure assessment indicates no risk for the sediment compartment (all Risk Characterisation Ratios (RCR) < 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information), no risk for the sediment compartment is indicated and further tests are not needed.
In addition, the substance is considered to be readily biodegradable and according to the Guidance on information requirements and chemical safety assessment, Chapter R.7b (ECHA, 2017), readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs). Therefore, this substance has a low potential for persistence and chronic exposure of sediment organisms is unlikely.
Based on the aquatic toxicity data, N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) is classified as Aquatic Acute 1 and Aquatic Chronic 3 according to CLP. Sediment testing is not relevant for classification purposes and thus no change in classification is triggered by sediment data. Since no high adsorption or binding behavior to sediment particles is expected and the all RCR’s are < 1, no risk for the sediment compartment is indicated and no further testing is considered necessary.
Moreover, the bioaccumulation potential of N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) is expected to be low i.e. based on log D of 3.52 and 3.55 (pH 7), excretion processes and low BCF values of 95.39 – 264.5 L/kg wet-wt (BCFBAF v3.01, Arnot-Gobas, including biotransformation, upper trophic) and 3.16 L/kg wet-wt (regression-based method; for all three constituents and both log Kow values) based on QSAR. Therefore, this substance has a low potential for persistence and chronic exposure of sediment organisms is unlikely.
Based on the low adsorption potential, a RCR < 1, low bioaccumulation potential and low potential for persistence, it can be concluded that N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) is not expected to be harmful to sediment organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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