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EC number: 945-920-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study with rats, performed equivalent to OECD 401 guidelines, an LD50 of 7.73 mL/kg bw was determined. In a supporting acute oral toxicity study with rats, performed equivalent to OECD 401 guideline, an LD50 >5000 mg/kg bw was determined.
Therefore no classification is required for acute oral Toxicity.
In an acute dermal toxicity study with rabbits, performed equivalent to OECD 402 guideline, an LD50 >5000 mg/kg bw was determined.
Therefore no classification is required for acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 13, 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study meets the EC Standards (conducted equivalent to OECD 401). Non GLP. Deviations: no details on test material, limited details on test animals and environmental conditions. However, dose, number of animals and observation period and considering mortality observed, the result is considered reliable with restrictions.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no details on test material, limited details on test animals and environmental conditions.
- GLP compliance:
- no
- Remarks:
- not present at the time of performance.
- Test type:
- acute toxic class method
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Compound A - 7155 (1-Formyl1-Methyl-4-(4methyl-dentan-1-yl)-Cyclohexane)
- Description: colorless liquid
Please note that although the substance is stated as a mono-constituent substance 21-Formyl1-Methyl-4-(4methyl-dentan-1-yl)-Cyclohexane in the report, recent analytical data had been determined the substance to be a multi-constituent (Reaction mass of 1-methyl-3-(4-methylpentyl)-3-cyclohexene-1-carboxaldehyde and 1-methyl-4-(4-methylpentyl)-3-cyclohexene-1-carboxaldehyde). As the chemical manufacturing process has not changed since the report was written, the recent analytical information is relevant to the batch which was tested. - Species:
- rat
- Strain:
- other: Holtzman
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 100 to 125 g
- Housing: in raised wire mesh cages
- Diet: regular diet of Fox Blox - Route of administration:
- other: intragastrically (gavage)
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- GAVAGE METHOD: rigid stomach tube, single dose.
MAXIMUM DOSE VOLUME APPLIED: 8.0 mL/kg) body weight - Doses:
- 1.0, 1.3, 6.0, 6.2, 6.5, 7.0, 7.5 and 8.0 mL/kg body weight. We assume dose 1.0 and 1.3 should read 10 and 13 mL/kg considering the results.
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Clinical signs for observation: loss in body weight, convulsions, ataxia, emesis and or death
- Necropsy of survivors performed: no - Statistics:
- The method of Litchfield, V.T. and Wilcoxon, F., Journal of Pharmacology and Experimental Therapeutics, Vol/ 96, p.99, 1949 was used in calculating the oral LD50.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 7.73 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 7 - 8.5
- Mortality:
- 6.0 mL/kg: 0/10
6.2 mL/kg: 1/10
6.5 mL/kg: 3/10
7.0 mL/kg: 3/10
7.5 mL/kg: 4/10
8.0 mL/kg: 6/10
10 mL/kg: 8/10
13 mL/kg: 10/10 - Clinical signs:
- other: Not reported.
- Gross pathology:
- No data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study with rats, performed equivalent to OECD 401 guidelines, an LD50 of 7.73 mL/kg bw was determined.
- Executive summary:
Compound A - 7155 (1-Formyl1-Methyl-4-(4methyl-dentan-1-yl)-Cyclohexane) was tested in an acute oral toxicity study with rats, performed equivalent to OECD 401 guideline. Deaths occurred starting at the 6.2 mL/kg dose level.
Based on the results, an LD50 of 7.73 mL/kg bodyweight was determined.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- October, 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study meets the EC Standards (conducted equivalent to OECD 401). Non GLP. Deviations: lack of study design details in the report, no details on test material, no details on test animals and environmental conditions. Only a very short description is reported. However, dose, number of animals and observation period and considering mortality observed, the result is considered reliable with restrictions.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- lack of study design details in the report, no details on test material, no details on test animals and environmental conditions.
- GLP compliance:
- no
- Remarks:
- not present at the time of performance.
- Test type:
- acute toxic class method
- Limit test:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 77-449, Vernaldehyde
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- 5000 mg/kg body weight.
- No. of animals per sex per dose:
- 10 (in total)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: at least 6 observation days
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- One animal died on day 6.
- Clinical signs:
- other: Diarrhea, slight lethargy, ptosis.
- Gross pathology:
- The following observations were observed:
Intestines yellow areas (1 animal), intestines bloated (1 animal), stomach yellow areas (1 animal), liver mottled (1 animal), lungs dark areas (7 animals), dark kidney (2 animals), pale kidney (1 animal) and dark spleen (1 animal). - Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study with rats, performed equivalent to OECD 401 guideline, an LD50 >5000 mg/kg bw was determined.
- Executive summary:
Vernaldehyde was tested in an acute oral toxicity study with rats, performed equivalent to OECD 401 guideline. One out of ten animals died. Clinical signs were diarrhea, slight lethargy and ptosis. The following necropsy observations were observed:
Intestines yellow areas, intestines bloated, stomach yellow areas, liver mottled, lungs dark areas, dark kidney, pale kidney and dark spleen. Based on the results, an LD50 >5000 mg/kg bodyweight was determined.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 7 730 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October, 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study meets the EC Standards (conducted equivalent to OECD 402). Non GLP. Deviations: lack of study design details in the report, no details on test material, limited details on test animals and environmental conditions. Only a very short description is reported. However, dose, number of animals and observation period and considering mortality observed, the result is considered reliable with restrictions.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- lack of study design details in the report, no details on test material, limited details on test animals and environmental conditions.
- GLP compliance:
- no
- Remarks:
- not present at the time of performance
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 77-449, Vernaldehyde
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
No data
ENVIRONMENTAL CONDITIONS
No data - Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- No data
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10 (in total)
- Control animals:
- not required
- Details on study design:
- No data
- Statistics:
- None.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: None observed.
- Gross pathology:
- The following observations were observed:
Dark liver (3 animals), liver mottled (1 animal), pale kidney (1 animal) and exudate anogenital (1 animal). - Other findings:
- All 10 animals showed severe redness and moderate edema.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity study with rabbits, performed equivalent to OECD 402 guideline, an LD50 >5000 mg/kg bw was determined.
- Executive summary:
Vernaldehyde was tested in an acute dermal toxicity study with rabbits, performed equivalent to OECD 402 guideline. No deaths occurred. The following necropsy observations were observed: Dark liver, liver mottled, pale kidney and exudate anogenital. All animals showed severe redness and moderate edema. Based on the results, an LD50 >5000 mg/kg bodyweight was determined.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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