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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 96 hours
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Published data on key component of the substance
The substance dissociates in water under environmental conditions and an assessment of toxicity can be performed by considering the key dissociated ions present in water.
The three ions will be Manganese, sulphate and glycinate - Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Principles of method if other than guideline:
- Performed to US Federal standards, including animal welfare rules
- GLP compliance:
- not specified
- Remarks:
- Academic research
- Specific details on test material used for the study:
- Hydrated form used.
Results are adjusted to reflect anhydrous and total Mn - Analytical monitoring:
- yes
- Remarks:
- No detail, but flow-through system calibrated and validated
- Vehicle:
- no
- Test organisms (species):
- Salmo trutta
- Details on test organisms:
- Brown trout
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- Reported as 'hard water' at over 150 mg/l Calcium carbonate
- Test temperature:
- Reported to be in line with Federal animal welfare (10 - 15 C required)
- pH:
- Not adjusted
- Nominal and measured concentrations:
- No details on treatment levels reported
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 198 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- Calculated based on Mn content
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 49 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Mn
- Basis for effect:
- mortality (fish)
- Details on results:
- No direct observations included
- Conclusions:
- Toxicity of MnSO4 resulted in an apparent toxic effect of 49 mg/l Mn.
Note that work by the same institute on other Mn salts show similar range of toxicity to Mn suggesting that the counter ion is not critical when fully dissolved in water. However, there is apparent variation between species and hardness with greater toxicity in soft water.
Based on the toxicity of Mn, it is predicted that the LC50 of the substance is 198 mg/l
Reference
Description of key information
Toxicity of MnSO4 resulted in an apparent toxic effect of 49 mg/l Mn.
Note that work by the same institute on other Mn salts show similar range of toxicity to Mn suggesting that the counter ion is not critical when fully dissolved in water. However, there is apparent variation between species and hardness with greater toxicity in soft water.
Based on the toxicity of Mn, it is predicted that the LC50 of the substance is 198 mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- ca. 198 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.