Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-572-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
5-[C11-12 (branched) alkyl]-2-hydroxybenzaldehyde oxime does not bioaccumulate in aquatic or sediment organisms.
Key value for chemical safety assessment
- BCF (aquatic species):
- 159 dimensionless
Additional information
Since no studies assessing the bioaccumulation potential of 5-(C11-C12 alkyl, branched)-2-hydroxy-benzaldehyde is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related source substance Benzaldehyde, 2-hydroxy-5-nonyl, oxime, branched (CAS 174333-80-3) was conducted. The read across justification document is attached to chapter 13.
The bioaccumulation study with the source substance was performed according to GLP and OECD guideline 305 using Oncorhynchus mykiss as test organism. The fish were exposed for 4 weeks followed by a three week depuration period. Test substance concentrations of 7 and 35 µg/L were used. Based on whole body weight and total fat and assuming steady state, for both concentrations a plateau was reached after 6 days. The BCF is determined to be 138 and 159, respectively. While one fish died, neither abnormal behaviour nor abnormal growth was observed. Depuration was achieved after 4 and 8 days, respectively. Given the low measured BCF value (which is much lower than the threshold value of 2000 listed in ECHAs Guidance on information requirement and chemical safety assessment Chapter R.11) and the depuration, it can be concluded that the test substance does not accumulate remarkably in fish. Based on the high structural similarity which leads to similar behavior in the environment (as explained in the analogue justification document) this conclusion can also be considered true for 5-(C11-C12 alkyl, branched)-2-hydroxy-benzaldehyde.
This conclusion is supported by a valid QSAR calculation provided in the dossier as well as a bioaccumulation study listed in the REACh dossier of Phenol, dodecyl-, branched (CAS 121158-58-5). The QSAR calculation (using the regression method as well as the Arnot-Gobas method) resulted in BCF values between 126.6 and 1210, which is below the ECHA criterion (of 2000) indicating a substance to be bioaccumulative. The OECD guideline study (OECD 305) resulted in BCF values between 289 and 1601 and thus confirmed the results of the QSAR calculation. Unfortunately, a robust study summary cannot be provided due to ownership reasons.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)