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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test item, Cesium Tungsten Oxide, was administered to 6 females Wistar rats at a limit dose of 2000 mg/kg. The limit dose did not cause death or evident signs of toxicity. During the follow up period, no other signs of intoxication, change of health, nor any other adverse reactions were displayed. The body weight of animals increased between week 1 and week 2, except 1 animal. The macroscopical examination of the animals at the end of the study did not reveal treatment-related changes. The LD50 of the test item was thus determined to be greater than 2000 mg/kg body weight after single oral administration to Wistar rats.
The test item Cesium Tungsten Oxide does not meet GHS classification criteria as based on study results the LD50 cut off value is equal to or greater than 5000 mg/kg body weight, after single oral administration to Wistar rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 January to 14 February 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No. of test material: Lot B0345
- Purity: >99%
- Appearance: dark blue powder - Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dobrá Voda, Slovak Republic
- Females nulliparous and non-pregnant: Yes
- Age at study initiation: 8-12 wks
- Weight at study initiation: 175-200 g
- Fasting period before study: overnight
- Housing: housed in plastic cages suspended on stainless steel racks, up to 3 animals per cage
- Diet: The laboratory food ssniff (Spezialdiäten GmbH, Germany) was offered at recommended doses each day approximately at the same time.
- Water: ad libitum
- Acclimation period: acclimated under the conditions identical to the conditions during the experiment 5 days prior to the start of treatment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22.8 ± 0.5° C
- Humidity (%): 54.0 ± 2.0 %
- Photoperiod (hrs dark / hrs light): 12-hour light /12-hour dark cycle - Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Justification for choice of vehicle: Olive oil is a standard vehicle according to OECD TG 423
- Lot/batch no.: L63417
- The required amount of the test item (according to the body weight and dose) was mixed with vehicle (olive oil) shortly before administration.
CLASS METHOD
- Rationale for the selection of the starting dose: The starting dose could be selected from the fixed dose levels of 5, 50, 300, and 2000 mg/kg body weight. Available information indicated that the test item is likely to be non-toxic with regard to acute toxicity. A limit dose of 2000 mg/kg body weight was therefore used as a starting dose. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed individually immediately after administration of the test item and 0.5, 1, 2, and 4 hours later.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology; Clinical observations included: changes in skin, fur, eyes, mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity, and behavioural pattern. Particular attention was given to potential neurologic endpoints such as tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma. - Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: The limit dose of 2000 mg/kg body weight did not cause death or evident signs of toxicity. During the follow up period, no other signs of intoxication, change of health, nor any other adverse reactions were displayed.
- Gross pathology:
- All animals were necropsied. During necropsy, no macroscopic findings were observed.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item, Cesium Tungsten Oxide, was administered to 6 females Wistar rats at a limit dose of 2000 mg/kg. The limit dose did not cause death or evident signs of toxicity. During the follow up period, no other signs of intoxication, change of health, nor any other adverse reactions were displayed. The body weight of animals increased between week 1 and week 2, except 1 animal. The macroscopical examination of the animals at the end of the study did not reveal treatment-related changes. The LD50 of the test item was thus determined to be greater than 2000 mg/kg body weight after single oral administration to Wistar rats.
The test item Cesium Tungsten Oxide does not meet GHC classification criteria as based on study results the LD50 cut off value is equal to or greater than 5000 mg/kg body weight, after single oral administration to Wistar rats. - Executive summary:
The test item, Cesium Tungsten Oxide, was administered to 6 females Wistar rats at a limit dose of 2000 mg/kg. The limit dose did not cause death or evident signs of toxicity. During the follow up period, no other signs of intoxication, change of health, nor any other adverse reactions were displayed. The body weight of animals increased between week 1 and week 2, except 1 animal. The macroscopical examination of the animals at the end of the study did not reveal treatment-related changes. The LD50 of the test item was thus determined to be greater than 2000 mg/kg body weight after single oral administration to Wistar rats.
The test item Cesium Tungsten Oxide does not meet GHS classification criteria as based on study results the LD50 cut off value is equal to or greater than 5000 mg/kg body weight, after single oral administration to Wistar rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
No deaths were reported following exposure of 6 female rats to a limit dose of 2,000 mg/kg bw. Therefore, the test substance does not meet the criteria for classification for acute oral toxicity according to the Regulation (EC) No 1272/2008 as amended.
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