Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 813-050-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to REACH Annex XI, 2. TESTING IS TECHNICALLY NOT POSSIBLE, Testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance: e.g. very volatile, highly reactive or unstable substances cannot be used, mixing of the substance with water may cause danger of fire or explosion or the radio-labelling of the substance required in certain studies may not be possible. The guidance given in the test methods referred to in Article 13(3), more specifically on the technical limitations of a specific method, shall always be respected.
As depicted in more detail in the attached Expert Statement on the reactions of Isocyanates and Di-isocyanates (e.g. DETDI) with water, Isocyanates have the possibility to react under different pH-conditions in water.
Under neutral and acidic conditions first formation of unstable carbamic acid takes place. This decomposes immediately to the corresponding amine (neutral conditions) or ammonium salt (acidic conditions). Acidic conditions (catalysis) accelerate the formation of unstable carbamic acid.
Under basic conditions formation of carbamic acid anion should occur which does not decompose to the amine and carbon dioxide because no proton is available. The carbamic acid anion should be stable under basic conditions.
Isocyanates are capable to react with water via carbamic acid to the corresponding amine and carbon dioxide, the resulting amines are capable to react with isocyanates to form urea-derivatives. As isocyanates bear two isocyanate-groups, these molecules have the possibility to react further with water to form polyurea.
Further, experiments were performed by an external laboratory (attached) to evaluate also practically the feasibility of ecotoxicity testing. As proposed above using common literature data, the pre-test for Ecotoxicity testing show that DETDI is rapidly transformed into another substance. However, the design of the pre-test does not allow determination of neither the half-life time nor the degradation products for DETDI due to the anticipated rapid polymerization of the hydrolysis products. Thus, the author concluded that testing DETDI in aquatic studies would not result in reliable conclusions concerning possible effects during testing.
Last but not least, interim results for the feasibility of hydrolysis testing showed that in pure water and different buffer solutions DETDI degraded immediately after preparation of the standard and analysis. By comparing the spectra of the peaks in Acetonitrile and in buffer solution, DETDI could not be observed in the aqueous samples, and a few unknown products were found.
So in summary, water solubility testing of DETDI is technically not possible, as it reacts immediately with water to unknown products, and so, the Waiving criteria according to Annex XI of REACH are met and testing can be omitted.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.