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EC number: 700-906-2 | CAS number: 22450-96-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
After 72 hours of exposure of the unicellular green alga Pseudokirchneriella subcapitata to SABoTBA, the ErC50 and EyC50, based on mean measured concentrations, were >28.9 mg/L (14% inhibition) and 28.2 mg/L, respectively.
The no observed effect concentration (NOEC) at 72 hours for growth rate and yield was 7.56 mg/L, and the lowest observed effect concentration (LOEC) was 28.9 mg/L based on mean measured concentrations.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 28.9 mg/L
- EC10 or NOEC for freshwater algae:
- 7.56 mg/L
Additional information
The effect of SABoTBA on the growth of the unicellular green alga Pseudokirchneriella subcapitata was assessed under non-axenic conditions.
The study was conducted in accordance with EC Methods for Determination of Ecotoxicity, Annex IV to Commission Regulation (EC) No 761/2009 Part C, Method 3 “Freshwater Algae and Cyanobacteria, Growth Inhibition Test” and Procedure 201 of the “Guidelines for Testing of Chemicals” of the Organisation for Economic Co-operation and Development: Freshwater Alga and Cyanobacteria, Growth Inhibition Test” (2006, corrected 2011).
Triplicate algal cultures, with an initial cell density of ca. 1 x 104/mL, were exposed to SABoTBA dissolved in algal nutrient medium at nominal concentrations of 0.008, 0.030, 0.080, 0.260, 0.820, 2.64, 8.44 and 27.0 mg/L. The test media were prepared in OECD medium from an aqueous stock solution, which was made by the direct addition of the test substance to the dilution medium. The cultures were incubated in an orbital incubator under continuousp illumination at temperatures ranging from 21.4 to 23.0°C for 72 hours.
At the start of the test, the measured levels of SABoTBA in samples of the test cultures ranged between 88 and 113% of their nominal values. After 72 hours, the measured levels ranged between 60 and 102% of their nominal values (between 59 and 90% of their starting values). The greatest losses were observed at the lower test concentrations. Based on the geometric mean, the overall measured levels of SABoTBA were 0.00668, 0.0221, 0.0589, 0.212, 0.719, 2.39, 7.56 and 28.9 mg/L. These values were used in the calculation of study end-points.
Cell numbers were counted daily to monitor growth. The test results are expressed in terms of the growth rate and yield. The following values were derived from the data:
Parameter |
Endpoint |
SABoTBA (mg/L) |
|
|
|
Growth rate |
EC10 |
25.8 [25.5 & 28.3] |
EC50 |
> 28.9 [14% inhibition] |
|
NOEC |
7.56 |
|
LOEC |
28.9 |
|
|
|
|
|
|
|
Yield |
EC10 |
9.69 [7.91 & 11.1$] |
EC50 |
28.2 [25.8 & 31.2$] |
|
NOEC |
7.56 |
|
LOEC |
28.9 |
|
|
|
|
[ ] 95% confidence limits $ Confidence interval may be unreliable due to goodness of curve fit NOEC No observed effect concentration LOEC Lowest observed effect concentration |
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