Registration Dossier
Registration Dossier
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Reaction mass of (1R,4S,4aR,8R,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8S,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1R,4S,4aR,8S,8aS)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one and (1S,4R,4aS,8R,8aR)-9-(dichloromethylidene)-8-hydroxyoctahydro-1,4-methanonaphthalen-5(1H)-one
EC number: 700-770-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
approx. LD50 (oral, rat, screening level study): >300 mg/kg bw
approx. LD50 (dermal, rat, screening level study): > 2000 mg/kg bw
Key value for chemical safety assessment
Additional information
Available information from screening level studies:
approx. LD50 (oral, rat): >300 mg/kg bwapprox. LD50 (dermal, rat): > 2000 mg/kg bw
Only two screening level studies are available for acute oral and dermal toxicity. The results given above provide useful information about the corresponding properties of the substance. However the reliability, relevance and adequacy of the data are considered as limited and an overall reliability rating of 3 (= not reliable, according to the scoring system of Klimisch et al.) has been assigned. As a consequence, these data are not adequate for risk assessment and classification and labelling purposes.
Justification for classification or non-classification
Due to the low overall reliability rating of the available studies (see above under "Discussion"), the corresponding data are not adequate for a definitive decision about classification according to Regulation (EC) 1272/2008.
Based on the available information the substance does not meet the criteria for classification for "acute oral toxicity" under Regulation (EC) 1272/2008, Annex I, Part 3, 3.1.2; reason for non-classification: inconclusive.
Based on the available information the substance does not meet the criteria for classification for "acute dermal toxicity" under Regulation (EC) 1272/2008, Annex I, Part 3, 3.1.2; reason for non-classification: inconclusive.
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