Registration Dossier
Registration Dossier
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EC number: 611-930-7 | CAS number: 60045-26-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Two new GLP biodegradation studies have been performed with 3-PPB to internationally accepted guidelines, the OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) and the OECD guideline 310 (CO2 headspace test). 3-PPB was biodegrading in both tests but only in the OECD310 test was the substance deemed readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Two new GLP biodegradation studies have been performed with 3-PPB. These two studies were performed to internationally accepted guidelines, the OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) and the OECD guideline 310 (CO2 headspace test). In the manometric respirometry test, 3-PPB was degrading quickly the first two days and degradation continued consistently after that point but at a lower rate and plateaued below the pass level of 60%. Therefore in the OECD 301F test, 3-PPB was determined not to be readily biodegradable. Because of the stringency of the screening methods, low biodegradation values do not necessarily mean that the test substance is not biodegradable under environmental conditions, but indicate that more work is necessary to establish biodegradability. Therefore a decision was made to investigate the biodegradability of 3-PPB further in the "CO2 headspace test" (OECD 310) because the test has been used previously in cases of poorly soluble substances. This test has been successfully completed and demonstrated that production of CO2 by mixtures containing Kalama® K-Flex® 613 was above 10% of the theoretical maximum by Day 3 (41%), at 60% by day 7 and 92% at the end of the test on Day 28. Substances are considered to be readily biodegradable in this test if CO2 production is equal to or greater than 60% of the theoretical value within ten days of the level achieving 10%. Kalama® K-Flex® 613 can, therefore, be considered readily biodegradable.
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