Registration Dossier
Registration Dossier
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EC number: 606-203-6 | CAS number: 1902-01-8
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study conducted in compliance with GLP regulations; analogy to structural similar substance (sodiumpanthoate)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Version / remarks:
- Cited as Directive 88/302/EEC, C.11
- GLP compliance:
- yes
Test material
- Reference substance name:
- sodium (2R)-2,4-dihydroxy-3,3-dimethyl-butanoate
- Cas Number:
- 60979-68-2
- Molecular formula:
- C6 H11 Na O4
- IUPAC Name:
- sodium (2R)-2,4-dihydroxy-3,3-dimethyl-butanoate
- Details on test material:
- Butanoic acid, 2,4-dihydroxy-3,3-dimethyl, D-, sodium salt (Natriumpantoat roh, ber. 100%)
CAS No.: 60979-68-2
Batch No.: B 671 mixed sample
Content/Composition: ca. 20 % main component
79 % water
1.5 % NaOH
388 ppm NH3
31 ppm HCN
(according to Analytical Laboratory Report No. 99L00017)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- activated sludge, domestic
Study design
- Limit test:
- yes
Test conditions
- Nominal and measured concentrations:
- 1000 mg test substance/L (807 mg/l DOC) was the only concentration tested.
- Details on test conditions:
- Type: aquatic
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 30 min
- Dose descriptor:
- EC0
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Any other information on results incl. tables
No inhibition of respiration was observed up to a concentration of 1000 mg/L.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
