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EC number: 612-179-8 | CAS number: 61597-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The substance menthyl lactate showed low acute toxicity to freshwater invertebrates (Daphnia magna). The EC50 based on immobilisation was between 125 mg/L (nominal, EC0) and 271.06 mg/L (geometric mean of measured concentration over 48 hours, EC100).
Key value for chemical safety assessment
Additional information
A study on the acute toxicity of menthyl lactate to freshwater invertebrates (Daphnia magna) was performed under static conditions over a period of 48 hours. The suitability of the test system was confirmed in a study with the positive reference substance potassium dichromate. The substance was undergoing relatively rapid hydrolysis under the test conditions. The main metabolite of hydrolysis was L-menthol. Due to the observed hydrolysis of the test substance, nominal concentrations were confirmed by gas chromatography analysis at the start of the experiment and at 24-hour intervals thereafter. A hundred percent immobilisation was seen at the highest test concentration (nominal 500 mg/L, geometric mean of measured concentrations over 48 hours 271.06 mg/L) - 90% of daphnids were already immobile after 24 hours at this test concentration. No immobilisation after 48 hours was seen at the nominal test concentration of 125 mg/L (no analytical confirmation of nominal concentration). The EC50 value could not be determined appropriately and was in the range from 125 mg/L to 271.06 mg/L. This value was used in the hazard assessment for the aquatic environment. Since no marine toxicity tests were available, the data generated with freshwater species were also used for the hazard assessment for the marine aquatic environment. The EC50 value for methyl lactate was significantly greater than that of its major breakdown product in water - L-menthol - which produced and EC50 value of 26.6 mg/L with daphnids in an aquatic toxicity test over a period of 48 hours.
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